ChemicalBook > CAS DataBase List > 4-Benzylpiperidine

4-Benzylpiperidine

Product Name
4-Benzylpiperidine
CAS No.
31252-42-3
Chemical Name
4-Benzylpiperidine
Synonyms
NSC 30346;AKOS BBS-00003617;4-Benzylpiperdine;4-benzyl-piperidin;4-BENZYLPIPERIDINE;4-Benzylpiperidine99%;Piperidine, 4-benzyl-;LABOTEST-BB LTBB000752;4-Benzylpiperidine,98%;4-Benzylpiperidine >
CBNumber
CB9141122
Molecular Formula
C12H17N
Formula Weight
175.27
MOL File
31252-42-3.mol
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4-Benzylpiperidine Property

Melting point:
6-7 °C (lit.)
Boiling point:
279 °C (lit.)
Density 
0.997 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.537(lit.)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
form 
Viscous Liquid
pka
10.58±0.10(Predicted)
color 
Clear colorless to yellow
BRN 
132339
CAS DataBase Reference
31252-42-3(CAS DataBase Reference)
EPA Substance Registry System
Piperidine, 4-(phenylmethyl)- (31252-42-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
TM4728000
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
142360
Product name
4-Benzylpiperidine
Purity
99%
Packaging
25g
Price
$57.2
Updated
2024/03/01
TCI Chemical
Product number
B0387
Product name
4-Benzylpiperidine
Purity
>99.0%(GC)
Packaging
25mL
Price
$32
Updated
2022/04/27
TCI Chemical
Product number
B0387
Product name
4-Benzylpiperidine
Purity
>99.0%(GC)
Packaging
250mL
Price
$198
Updated
2021/12/16
Alfa Aesar
Product number
B23883
Product name
4-Benzylpiperidine, 98%
Packaging
100g
Price
$91.3
Updated
2021/12/16
Alfa Aesar
Product number
B23883
Product name
4-Benzylpiperidine, 98%
Packaging
25g
Price
$34.1
Updated
2021/12/16
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4-Benzylpiperidine Chemical Properties,Usage,Production

Chemical Properties

clear colourless to yellow viscous liquid.

Uses

4-Benzylpiperidine was studied as acid corrosion inhibitor for iron. It was also used to study potential utility of dopamine-welective releaser as a treatment for cocaine dependence. In an assay of cocaine discrimination, 4-Benzylpiperidine had the most rapid onset and shortest duration of action.

Preparation

4-Benzylpiperidine can be prepared by reacting 4-cyanopyridine with toluene. Catalytic hydrogenation of the pyridine ring then completes the synthesis.

Application

Reactant for synthesis of:
Antiproliferatives
GABA uptake inhibitors
Pyridines
Histamine H3 antagonists
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseases
Antiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution

Synthesis Reference(s)

Synthesis, p. 741, 1980 DOI: 10.1055/s-1980-29196

General Description

4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence.

Biochem/physiol Actions

4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B, with IC50 values of 0.02 mM and 2 mM respectively. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively . It has a fast onset of action and a short duration. It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.

4-Benzylpiperidine Preparation Products And Raw materials

Raw materials

Diethylene glycol Acetic anhydride Potassium hydroxide Calcium chloride Potassium carbonate Hydrazine hydrate Trifluoroacetic acid Sodium borohydride Aluminum chloride Tetrahydrofuran Benzene 1,2-Dichloroethane Lithium Aluminum Hydride Hydrochloric acid Isonipecotic acid Dichloromethane Sodium hydroxide Triethylsilane Diisopropyl ether Isopropyl alcohol Thionyl chloride

Preparation Products

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4-Benzylpiperidine Suppliers

Americas 1 Belgium 1 China 118 Czech Republic 1 Europe 3 France 3 Germany 8 India 9 Italy 1 Japan 6 Slovakia 1 South Korea 2 Switzerland 3 Ukraine 1 United Kingdom 10 United States 35 Global 203
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View Lastest Price from 4-Benzylpiperidine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-Benzylpiperidine 31252-42-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-19
Shanghai CRM New Material Technology Co., LTD
Product
4-benzylpiperidine 31252-42-3
Price
US $10.00-15.00/g
Min. Order
10g
Purity
99%
Supply Ability
2546245
Release date
2022-09-23
Shaanxi Dideu Medichem Co. Ltd
Product
4-Benzylpiperidine 31252-42-3
Price
US $0.00-0.00/Kg
Min. Order
100G
Purity
99.0%+
Supply Ability
100 tons
Release date
2020-01-17

31252-42-3, 4-BenzylpiperidineRelated Search:

4-(4-FLUOROBENZOYL)PIPERIDINE P-TOLUENESULFONATE KETANSERIN TARTRATE 4-(4-Fluorobenzoyl)piperidine hydrochloride PIRENPERONE (4-METHOXYPHENYL)(4-PIPERIDYL)METHANONE HYDROCHLORIDE 4-BENZYL-4-HYDROXYPIPERIDINE alpha,alpha-Diphenyl-4-piperidinomethanol Ifenprodil Terfenadine 4-BENZOYLPIPERIDINE HYDROCHLORIDE BENZETIMIDE Diphenylpiperidin-4-ylmethanol hydrochloride Ketanserin 4-Benzylpiperidine 1-(2-Aminoethyl)-4-benzylpiperidine METHYL 1-BENZYL-PIPERIDINE-3-CARBOXYLATE 4-(3-TRIFLUOROMETHYL-BENZYL)-PIPERIDINE HYDROCHLORIDE 1-BENZYLPIPERIDINE-3-CARBOHYDRAZIDE

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  • 4-benzyl-piperidin
  • LABOTEST-BB LTBB000752
  • PHENYL(4-PIPERIDYL)METHANE
  • Piperidine, 4-(phenylmethyl)-
  • Piperidine, 4-benzyl-
  • 4-BENZYLPIPERIDINE
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  • ALPHA-(4-PIPERIDYL)TOLUENE
  • AKOS BBS-00003617
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  • alpha-(Piperidin-4-yl)toluene
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  • 4-BENZYLPIPERIDINE FOR SYNTHESIS
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