5-BROMO-2-METHOXY-3-CYANOPYRIDINE

Product Name: 5-BROMO-2-METHOXY-3-CYANOPYRIDINE
CAS No.: 884495-39-0
Chemical Name: 5-BROMO-2-METHOXY-3-CYANOPYRIDINE
Synonyms: 5-BroMo-2-Methoxy-3-aMino...;5-Bromo-2-methoxypyridin-3-amine;5-bromo-6-methoxypyridin-4-amine;3-PyridinaMine,5-broMo-2-Methoxy-;5-BROMO-2-METHOXY-3-AMINOPYRIDINE;5-BROMO-2-METHOXY-3-CYANOPYRIDINE;2-methoxy-3-amino-5-bromopyridine;5-BroMo-2-(Methyloxy)-3-pyridinaMine;3-Amino-5-bromo-2-methoxypyridine,96%;3-Amino-5-bromo-2-methoxypyridine 98%
CBNumber: CB91471022
Molecular Formula: C6H7BrN2O
Formula Weight: 203.04
MOL File: 884495-39-0.mol

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5-BROMO-2-METHOXY-3-CYANOPYRIDINE Property

Melting point:: 53-55℃
Boiling point:: 284.5±35.0 °C(Predicted)
Density: 1.622±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 1.98±0.20(Predicted)
Appearance: Off-white to light brown Solid
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C6H7BrN2O/c1-10-6-5(8)2-4(7)3-9-6/h2-3H,8H2,1H3
InChIKey: HJOOFLFWIISCAI-UHFFFAOYSA-N
SMILES: C1(OC)=NC=C(Br)C=C1N

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41-43
Safety Statements: 26-36/37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000451
Product name: 5-Bromo-2-methoxypyridin-3-amine
Purity: Aldrich
Packaging: 1g
Price: $463
Updated: 2023/06/20

TRC

Product number: B699685
Product name: 5-Bromo-2-methoxypyridin-3-amine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: V2296
Product name: 5-Bromo-2-methoxy-3-aminopyridine
Packaging: 25g
Price: $147
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA75231
Product name: 3-Amino-5-bromo-2-methoxypyridine
Packaging: 100g
Price: $350
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA75231
Product name: 3-Amino-5-bromo-2-methoxypyridine
Packaging: 250g
Price: $500
Updated: 2021/12/16

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5-BROMO-2-METHOXY-3-CYANOPYRIDINE Chemical Properties,Usage,Production

Uses

3-Amino-5-bromo-2-methoxypyridine is used as pharmaceutical intermediate.

Synthesis

152684-30-5

884495-39-0

General procedure for the synthesis of 3-amino-5-bromo-2-methoxypyridine from 5-bromo-2-methoxy-3-nitropyridine: To a solution of 5-bromo-2-methoxy-3-nitropyridine (19.0 g, 82 mmol) in ethyl acetate (300 mL) was added tin (II) chloride dihydrate (74 g, 328 mmol). The reaction mixture was stirred and refluxed for 3 hours (note: an exothermic phenomenon occurs at the beginning of the reaction, which gradually subsides after about 10 minutes, at which time the heating bath can be temporarily removed). After completion of the reaction, the reaction mixture was cooled to room temperature and concentrated under reduced pressure to a light yellow slurry. The slurry was poured into water (300 mL), 6 N sodium hydroxide solution (300 mL), ice (300 g), and dichloromethane (300 mL) were added, and stirred for 2 hours until most of the solids were dissolved. A small amount of insoluble material was removed by filtration, the organic phase was separated, dried over anhydrous sodium sulfate, filtered and evaporated to dryness. The residual brown oil was solidified by grinding with hexane, filtered and dried under vacuum to give the target product 3-amino-5-bromo-2-methoxypyridine (13.40 g, 81% yield) as a light green solid. Mass spectrum (electrospray ionization) m/e: 202.8 [M+H]+.

References

[1] Patent: US2014/134133, 2014, A1. Location in patent: Paragraph 0387
[2] Patent: WO2008/33854, 2008, A1. Location in patent: Page/Page column 74-75
[3] Patent: WO2014/22128, 2014, A1. Location in patent: Paragraph 0150
[4] Patent: US2014/234254, 2014, A1. Location in patent: Paragraph 0300; 0301; 0302
[5] Patent: CN103539777, 2016, B. Location in patent: Paragraph 0304; 0305

5-BROMO-2-METHOXY-3-CYANOPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-2-METHOXY-3-CYANOPYRIDINE Suppliers

China 187 Germany 1 India 9 United Kingdom 2 United States 14 Global 213

Pure Chemistry Scientific Inc.

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View Lastest Price from 5-BROMO-2-METHOXY-3-CYANOPYRIDINE manufacturers

Dideu Industries Group Limited

Product: 5-BROMO-2-METHOXY-3-CYANOPYRIDINE 884495-39-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Bromo-2-methoxypyridin-3-amine 884495-39-0
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-12

Career Henan Chemical Co

Product: 5-BROMO-2-METHOXY-3-CYANOPYRIDINE 884495-39-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-19

884495-39-0, 5-BROMO-2-METHOXY-3-CYANOPYRIDINERelated Search:

3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE 3-Pyridinamine, 5-chloro-2-methoxy- 5-AMINO-3-BROMO-2-METHYLPYRIDINE 5-Chloro-2-methyl-3-nitropyridine 3-Bromo-2-methoxy-5-nitropyridine 5-AMINO-3-BROMO-2-METHOXYPYRIDINE 5-BROMO-2-METHOXY-4-METHYLPYRIDINE 5-BROMO-2-METHOXY-3-NITRO-PYRIDINE 3-BROMO-2-METHOXY-6-PICOLINE 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE 2-Methoxy-3-nitropyridine 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL 2-Methoxy-3-fluoro-5-bromopyridine 6-Chloro-2-methoxy-3-nitropyridine 2-METHOXY-3,5-DIBROMO-PYRIDINE 2-Methoxy-5-nitro-3-picoline 2-Methoxy-3-(trifluoromethyl)pyridine 3-Iodo-2-methoxypyridine

5-BROMO-2-METHOXY-3-CYANOPYRIDINE

5-BROMO-2-METHOXY-3-AMINOPYRIDINE

5-BroMo-2-Methoxy-3-aMino...

5-Bromo-2-methoxypyridin-3-amine

3-PyridinaMine,5-broMo-2-Methoxy-

5-BroMo-2-(Methyloxy)-3-pyridinaMine

5-Bromo-2-methoxypyridin-3-amine, 3-Amino-5-bromopyridin-2-yl methyl ether

3-Amino-5-bromopyridin-2-yl methyl ether

2-methoxy-3-amino-5-bromopyridine

3-Amino-5-bromo-2-methoxypyridine 98%

3-Amino-5-bromo-2-methoxypyridine,96%

5-bromo-6-methoxypyridin-4-amine

5-BROMO-2-METHOXY-3-CYANOPYRIDINE ISO 9001：2015 REACH

884495-39-0

Heterocycle-Pyridine series

Pyridine