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PHLEOMYCIN

Product Name
PHLEOMYCIN
CAS No.
11006-33-0
Chemical Name
PHLEOMYCIN
Synonyms
nsc616586;CL990-cin;ZEOCIN(TM);PHLEOMYCIN;Zeocin powder;phleomycincomplex;PHLEOMYCIN USP/EP/BP;PHLEOMYCIN (STREPTOMYCES VERTICILLUS);hleoMycin froM streptoMyces verticillus;PHLEOMYCIN FROM STREPOMYCES VERTICILLUS,
CBNumber
CB9166103
Molecular Formula
C55H86N20O21S2
Formula Weight
0
MOL File
Mol file
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PHLEOMYCIN Property

Boiling point:
527.46°C (rough estimate)
Density 
1.3193 (rough estimate)
refractive index 
1.5600 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 10 mg/mL, clear, blue
form 
powder
color 
light blue
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36
RIDADR 
2811
WGK Germany 
3
RTECS 
SY0525000
F 
10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29419059
Toxicity
dog,LD50,intravenous,2500ug/kg (2.5mg/kg),Toxicology and Applied Pharmacology. Vol. 14, Pg. 590, 1969.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P9564
Product name
Phleomycin from Streptomyces verticillus
Purity
powder
Packaging
5mg
Price
$106
Updated
2024/03/01
Sigma-Aldrich
Product number
P9564
Product name
Phleomycin from Streptomyces verticillus
Purity
powder
Packaging
25mg
Price
$367
Updated
2024/03/01
Alfa Aesar
Product number
J67027
Product name
Phleomycin, 20 mg/ml in 5mM HEPES buffer, sterile-filtered
Packaging
5x1ml
Price
$430
Updated
2024/03/01
Alfa Aesar
Product number
J67027
Product name
Phleomycin, 20 mg/ml in 5mM HEPES buffer, sterile-filtered
Packaging
1ml
Price
$158
Updated
2023/06/20
Cayman Chemical
Product number
15549
Product name
Phleomycin
Purity
≥95%
Packaging
5mg
Price
$62
Updated
2024/03/01
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PHLEOMYCIN Chemical Properties,Usage,Production

Description

Phleomycin is a glycopeptide antibiotic from Streptomyces whose cytotoxic action results from its ability to cause DNA fragmentation. The ability of phleomycin to block mammalian cells from entering mitosis has made it useful in cancer therapy, most commonly in conjunction with other therapeutic modalities. Phleomycin is also used, in conjunction with a vector carrying the bleomycin resistance protein ble, as a selective agent in the transformation of yeast, plant cells, and mammalian cells.

Uses

Phleomycin is a metal-complexing DNA degrading antibiotic.

General Description

Phleomycin is a glycopeptide antibiotic and is a member of the bleomycin family.

Biochem/physiol Actions

Phleomycin can bind and intercalate with the DNA that leads to DNA strand breaks. It acts as an inhibitor of DNA replication.

in vitro

previous study found that the chromosomes could be cleaved into nucleosomes and degraded by phleomycin over significantly narrower dose ranges than by bleomycin. in addition, phleomycin also showed lower specificity for internucleosomal cleavage than bleomycin. moreover, it was found that the higher reactivity of phleomycin did not solely result from its higher rate of internucleosomal and intranucleosomal chromatin cleavage, since short phleomycin reactions always led to more extensive chromatin cleavage at low concentrations [1].

in vivo

a study of the in-vivo effects of phleomycin on meiosis of the mouse egg demonstrated a spectrum of damage to both first metaphase and second metaphase with polar body. the minimal effective dose in vivo of 2.5 μg/g of body weight could alter 28.3% of first metaphase figures and 50% of second metaphase cells [2].

References

[1] moore, c. w. internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeast. cancer research 48(23), 6837-6843 (1988).
[2] jagiello gm. action of phleomycin on the meiosis of the mouse ovum. mutat res. 1968 sep-oct;6(2):289-95.

PHLEOMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products

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PHLEOMYCIN Suppliers

China 107 Germany 1 Japan 1 South Korea 1 Switzerland 1 United Kingdom 5 United States 17 Global 133
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View Lastest Price from PHLEOMYCIN manufacturers

Henan Fengda Chemical Co., Ltd
Product
PHLEOMYCIN 11006-33-0
Price
US $8.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Dideu Industries Group Limited
Product
PHLEOMYCIN 11006-33-0
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-16
Career Henan Chemical Co
Product
PHLEOMYCIN 11006-33-0
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

11006-33-0, PHLEOMYCINRelated Search:

TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) PHENYLSELENOL COBALT(II) ACETYLACETONATE 2,4-PENTANEDIONE, SILVER DERIVATIVE SALCOMINE Ferric acetylacetonate Cupric acetylacetonate Ethyl isocyanoacetate Aluminum acetylacetonate TERT-BUTYL ISOCYANIDE METHYL ISOCYANOACETATE Tris(2,4-pentanedionato)chroMiuM(III) Tosylmethyl isocyanide DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Benzyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE N-BUTYLISOCYANIDE phleomycin D1

  • hleoMycin froM streptoMyces verticillus
  • CL990-cin
  • nsc616586
  • phleomycincomplex
  • PHLEOMYCIN
  • PHLEOMYCIN (STREPTOMYCES VERTICILLUS)
  • ZEOCIN(TM)
  • phleomycin from streptomyces verticillus
  • phleomycin from streptomyces*verticillus
  • PHLEOMYCIN FROM STREPOMYCES VERTICILLUS,
  • PHLEOMYCIN USP/EP/BP
  • Zeocin powder
  • 11006-33-0
  • C55H85N20O21S2CuHCl
  • C55H85O21N20S2CuxHCl
  • C55H86N20O21S2
  • BioChemical
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics N-S
  • antibiotic
  • Interferes with DNA SynthesisSpectrum of Activity
  • Mechanism of Action
  • L - ZMore...Close...
  • Antibacterial
  • Antibiotics
  • Antibiotics A to
  • Antibiotics by Application
  • Antibiotics N-SAntibiotics
  • Antineoplastic and Immunosuppressive AntibioticsAntibiotics
  • Chemical Structure Class
  • Genetic Marker SelectionAntibiotics
  • GlycopeptidesAntibiotics