PHLEOMYCIN
- Product Name
- PHLEOMYCIN
- CAS No.
- 11006-33-0
- Chemical Name
- PHLEOMYCIN
- Synonyms
- nsc616586;CL990-cin;ZEOCIN(TM);PHLEOMYCIN;Zeocin powder;phleomycincomplex;PHLEOMYCIN USP/EP/BP;PHLEOMYCIN (STREPTOMYCES VERTICILLUS);hleoMycin froM streptoMyces verticillus;PHLEOMYCIN FROM STREPOMYCES VERTICILLUS,
- CBNumber
- CB9166103
- Molecular Formula
- C55H86N20O21S2
- Formula Weight
- 0
- MOL File
- Mol file
PHLEOMYCIN Property
- Boiling point:
- 527.46°C (rough estimate)
- Density
- 1.3193 (rough estimate)
- refractive index
- 1.5600 (estimate)
- storage temp.
- 2-8°C
- solubility
- H2O: 10 mg/mL, clear, blue
- form
- powder
- color
- light blue
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- SY0525000
- F
- 10
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29419059
- Toxicity
- dog,LD50,intravenous,2500ug/kg (2.5mg/kg),Toxicology and Applied Pharmacology. Vol. 14, Pg. 590, 1969.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P9564
- Product name
- Phleomycin from Streptomyces verticillus
- Purity
- powder
- Packaging
- 5mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- P9564
- Product name
- Phleomycin from Streptomyces verticillus
- Purity
- powder
- Packaging
- 25mg
- Price
- $367
- Updated
- 2024/03/01
- Product number
- J67027
- Product name
- Phleomycin, 20 mg/ml in 5mM HEPES buffer, sterile-filtered
- Packaging
- 5x1ml
- Price
- $430
- Updated
- 2024/03/01
- Product number
- J67027
- Product name
- Phleomycin, 20 mg/ml in 5mM HEPES buffer, sterile-filtered
- Packaging
- 1ml
- Price
- $158
- Updated
- 2023/06/20
- Product number
- 15549
- Product name
- Phleomycin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
PHLEOMYCIN Chemical Properties,Usage,Production
Description
Phleomycin is a glycopeptide antibiotic from Streptomyces whose cytotoxic action results from its ability to cause DNA fragmentation. The ability of phleomycin to block mammalian cells from entering mitosis has made it useful in cancer therapy, most commonly in conjunction with other therapeutic modalities. Phleomycin is also used, in conjunction with a vector carrying the bleomycin resistance protein ble, as a selective agent in the transformation of yeast, plant cells, and mammalian cells.
Uses
Phleomycin is a metal-complexing DNA degrading antibiotic.
General Description
Phleomycin is a glycopeptide antibiotic and is a member of the bleomycin family.
Biochem/physiol Actions
Phleomycin can bind and intercalate with the DNA that leads to DNA strand breaks. It acts as an inhibitor of DNA replication.
in vitro
previous study found that the chromosomes could be cleaved into nucleosomes and degraded by phleomycin over significantly narrower dose ranges than by bleomycin. in addition, phleomycin also showed lower specificity for internucleosomal cleavage than bleomycin. moreover, it was found that the higher reactivity of phleomycin did not solely result from its higher rate of internucleosomal and intranucleosomal chromatin cleavage, since short phleomycin reactions always led to more extensive chromatin cleavage at low concentrations [1].
in vivo
a study of the in-vivo effects of phleomycin on meiosis of the mouse egg demonstrated a spectrum of damage to both first metaphase and second metaphase with polar body. the minimal effective dose in vivo of 2.5 μg/g of body weight could alter 28.3% of first metaphase figures and 50% of second metaphase cells [2].
References
[1] moore, c. w. internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeast. cancer research 48(23), 6837-6843 (1988).
[2] jagiello gm. action of phleomycin on the meiosis of the mouse ovum. mutat res. 1968 sep-oct;6(2):289-95.
PHLEOMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
PHLEOMYCIN Suppliers
View Lastest Price from PHLEOMYCIN manufacturers
- Product
- PHLEOMYCIN 11006-33-0
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- PHLEOMYCIN 11006-33-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-16
- Product
- PHLEOMYCIN 11006-33-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25