5-Hydroxyindole-2-carboxylic acid Property

Melting point:

249 °C (dec.) (lit.)

Boiling point:

309.06°C (rough estimate)

Density 

1.3312 (rough estimate)

refractive index 

1.5200 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

chloroform/ethanol (1:1): soluble50mg/mL, clear to slightly hazy, yellow to brown

form 

Fuming Liquid

pka

4.38±0.30(Predicted)

color 

Clear colorless to slightly yellow

BRN 

153214

CAS DataBase Reference

21598-06-1(CAS DataBase Reference)

Safety

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-21/22

Safety Statements 

26-36-36/37/39

WGK Germany 

3

HS Code 

29339900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

5-Hydroxyindole-2-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

light yellow to beige crystalline powder

Uses

• ;Reactant for preparation of indole C5-O-substituted seco-cyclopropylindole analogs as potential anticancer agents• ;Reactant for microwave combinatorial synthesis of indolic arylpiperazine derivatives as ligands for 5-HT1A, 5-HT2A, and 5-HT2C receptors1• ;Reactant for preparation of melanins as novel nature-inspired radioprotectors2• ;Reactant for preparation of 5-Hydroxyindole-2-carboxylic acid amides as histamine-3 receptor inverse agonists for the treatment of obesity3• ;Reactant for preparation of conformationally constrained peptidomimetic inhibitors of signal

Uses

5-Hydroxyindole-2-carboxylic acid was used in HPLC-amperometric detection of serotonin in plasma, platelets and urine.

Uses

A competitive antagonist of potentiation by glycine at the N-methyl-D-aspartate receptors that have been linked to neuronal death, assiciated to such afflictions as stroke and epilepsy.

Definition

ChEBI: 5-Hydroxyindole-2-carboxylic acid is an indolyl carboxylic acid.

General Description

5-Hydroxyindole-2-carboxylic acid on oxidation with KMnO₄ yields pyrrole-2,3,5-tricarboxylic acid.