ChemicalBook > CAS DataBase List > Amino-PEG4-acid

Amino-PEG4-acid

Product Name: Amino-PEG4-acid
CAS No.: 663921-15-1
Chemical Name: Amino-PEG4-acid
Synonyms: 1-AMino-3,6,9,12-tetraoxapentadecan-15-oic acid;NH2-PEG4-COOH;Amino-PEG4-acid;NH2-PEG4-CH2CH2COOH;3-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]propionic acid;NH2-PEG4-PA;AMINE-PEG4-COOH;Amino-PEG4-COOH;amino-dPEG4-acid;Amino-dPEGx-acid
CBNumber: CB92501434
Molecular Formula: C11H23NO6
Formula Weight: 265.3
MOL File: 663921-15-1.mol

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Amino-PEG4-acid Property

Boiling point:: 409.6±40.0 °C(Predicted)
Density: 1.134±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in water
pka: 4.28±0.10(Predicted)
form: powder
color: White
Appearance: white powder
InChI: InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)
InChIKey: DKUZHSDZSMQOGQ-UHFFFAOYSA-N
SMILES: C(O)(=O)CCOCCOCCOCCOCCN

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Safety

HS Code: 2942000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: QBD10244
Product name: Amino-dPEG<SUP>®</SUP><SUB>4</SUB>-acid
Purity: >95% (HPLC)
Packaging: 100 mg
Price: $175
Updated: 2025/07/31

Sigma-Aldrich

Product number: QBD10244
Product name: Amino-dPEG®4-acid
Purity: >95% (HPLC)
Packaging: 100MG
Price: $170
Updated: 2024/03/01

TRC

Product number: H289595
Product name: H2N-Dpeg(4)-COOH
Packaging: 100mg
Price: $110
Updated: 2021/12/16

Activate Scientific

Product number: AS114327
Product name: H2N-PEG4-CH2CH2COOH
Purity: 97+%
Packaging: 250mg
Price: $173
Updated: 2021/12/16

ChemPep

Product number: 282503
Product name: H2N-PEG4-CH2CH2COOH
Packaging: 1g
Price: $200
Updated: 2021/12/16

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Amino-PEG4-acid Chemical Properties,Usage,Production

Description

Amino-PEG4-acid is a very popular PEG linker. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond, long PEG spacer increases reagent's solubility in aqueous media.

Uses

H2N-Dpeg(4)-COOH, can be used in optical imaging of integrin αvβ3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers. Integrin αvβ3 plays great roles in tumor angiogenesis, invasion, and metastasis.

benefits

Amino-dPEG4-acid has a primary amine and propionic acid terminating opposite ends of a 16-atoms long (18.0 ?) polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (D = 1). Moreover, it is highly hydrophilic, and it imparts hydrophilicity to conjugates that incorporate it. Amino-dPEG4-acid is useful in many different applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.

reaction suitability

reaction type: Pegylations

Synthesis

581065-95-4

663921-15-1

General procedure for the synthesis of 1-amino-3,6,9,12-tetraoxapentadecan-15-oic acid tert-butyl ester from 1-amino-3,6,9,12-tetraoxapentadecan-15-oic acid: (4) 50 g of the amino end-product obtained in step (3) was dissolved in 100 mL of 3 M hydrochloric acid solution, heated to 60 °C and stirred continuously for 8 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted to neutral with alkali. Subsequently, the solvent was removed by rotary evaporator and the solid obtained was separated by filtration. The filtrate was dried with anhydrous sodium sulfate and concentrated again using a rotary evaporator to finally obtain 35 g of pure product.The NMR data are shown below:

IC 50

Cleavable Linker; PEGs

References

1. Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers. DOI:10.1021/mp800150r
2. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. DOI:10.1021/bc400050k
3. Microwave-mediated synthesis of labeled nucleotides with utility in the synthesis of DNA probes. DOI:10.1021/bc100013b
4. Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers. DOI:10.1021/bc800455p

Amino-PEG4-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Amino-PEG4-acid manufacturers

LAURENT

Product: NH2-PEG4-CH2CH2COOH 663921-15-1
Price: US $53.27/g
Min. Order: 10g
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-18

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: 1-amino-3,6,9,12-tetraoxapentadecan-15-oic acid 663921-15-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-11

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: NH2-PEG4-CH2CH2COOH 663921-15-1
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-05

663921-15-1, Amino-PEG4-acidRelated Search:

α,ω-dipropionic acid tetraethylene glycol Azido-PEG2-CH2CO2tBu FMoc-NH-8(ethylene glycol)-acetic acid Amino-PEG2-acid PENTAETHYLENE GLYCOL 3,6,9,12-tetraoxatridecylamine alpha-Azido-omega-hydroxy octa(ethylene glycol) FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID alpha, oMega-Dipropionic acid hexaethylene glycol (R)-N-(3,6,9,12-Tetraoxatridecyl)-alpha-lipoamide Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid N-BIOTINYL-3,6-DIOXAOCTANE-1,8-DIAMINE O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL Amino-PEG36-acid Amino-PEG25-t-butly ester Azido-PEG4-Acyl Chloride Azido-PEG10-S-methyl ethanethioate Amino-PEG3-t-butly acetate

3-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]propionic acid

1-AMino-3,6,9,12-tetraoxapentadecan-15-oic acid

Amino-PEG4-acid

α-amine-ω-propionic acid tetraethylene glycol

alpha-aMine-oMega-propionic acid tetraethylene glycol

H2N-PEG4-CH2CH2COOH

Amino-dPEGx-acid

amino-dPEG4-acid

Amino-PEG4-propionic acid

AMINE-PEG4-COOH

NH2-PEG4-COOH

Amino-PEG4-COOH

3-Amino(peg4)propionic acid

3-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]propanoic acid

1-Amino-3,6,9,12-tetraoxa-15-pentadecanoic Acid

NH2-PEG4-CH2CH2COOH

α-Amine-ω-propionic acid tetraethylene glycol,Amino-PEG4-acid

Propanoic acid, 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-

3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid

α-Amine-ω-propionic acid tetraethylene glycol hydrochloride

H2N-PEG4-CH2CH2COOH/Propanoic acid, 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-

NH2-PEG4-PA

Amino-dPEG??-acid (QBD-10244)

3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid - [A87192]

663921-15-1

C11H23NO6

PEG-COOH

peg