ChemicalBook > CAS DataBase List > GSK-2126458

GSK-2126458

Product Name
GSK-2126458
CAS No.
1086062-66-9
Chemical Name
GSK-2126458
Synonyms
CS-55;GSK212;GSK458;HYR-582;OMipalisib;GSK2126458;GSK-2126458;GSK2126458, >=98%;Omipalisib GSK458;GSK2126458 (GSK458)
CBNumber
CB92505205
Molecular Formula
C25H17F2N5O3S
Formula Weight
505.5
MOL File
1086062-66-9.mol
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GSK-2126458 Property

Melting point:
187-189℃
Boiling point:
715.6±70.0 °C(Predicted)
Density 
1.45
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
form 
Solid
pka
6.23±0.40(Predicted)
color 
White to Pale Yellow
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Safety

HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3161
Product name
GSK2126458
Purity
≥98% (HPLC)
Packaging
10MG
Price
$91.6
Updated
2022/05/15
Sigma-Aldrich
Product number
SML3161
Product name
GSK2126458
Purity
≥98% (HPLC)
Packaging
50MG
Price
$369
Updated
2022/05/15
Cayman Chemical
Product number
17377
Product name
GSK2126458
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
17377
Product name
GSK2126458
Purity
≥98%
Packaging
5mg
Price
$216
Updated
2024/03/01
Cayman Chemical
Product number
17377
Product name
GSK2126458
Purity
≥98%
Packaging
10mg
Price
$380
Updated
2024/03/01
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GSK-2126458 Chemical Properties,Usage,Production

Description

GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells.

Uses

A highly potent inhibitor of PI3K and the mammalian target of Rapamycin.

Definition

ChEBI: Omipalisib is a member of the class of quinolines that is quinoline which is substituted by pyridazin-4-yl and 5-[(2,4-difluorobenzene-1-sulfonyl)amino]-6-methoxypyridin-3-yl groups at positions 4 and 6, respectively. It is a highly potent inhibitor of PI3K and mTOR developed by GlaxoSmithKline and was previously in human phase 1 clinical trials for the treatment of idiopathic pulmonary fibrosis and solid tumors. It has a role as an autophagy inducer, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, a mTOR inhibitor, an antineoplastic agent, a radiosensitizing agent and an anticoronaviral agent. It is a member of quinolines, a difluorobenzene, a sulfonamide, an aromatic ether, a member of pyridines and a member of pyridazines.

target

p110α

storage

Store at -20°C

GSK-2126458 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-2126458 Suppliers

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View Lastest Price from GSK-2126458 manufacturers

Career Henan Chemical Co
Product
GSK-2126458 1086062-66-9
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

1086062-66-9, GSK-2126458Related Search:

daprodustat,GSK1278863 GSK1940029 GSK 189254A GSK2110183 gsk2200150a 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% AZD-3965 GSK1292263 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine GSK-3beta Inhibitor XXVI(GSK-3b) Cadmium sulfide AZD-8055 MK-2206 2HCl Pictilisib Erlotinib hydrochloride LY 294002 HYDROCHLORIDE Danirixin

  • GSK2126458
  • GSK-2126458
  • GSK2126458; GSK-2126458
  • 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
  • GSK2126458 (HYR-582)
  • CS-55
  • Omipalisib GSK2126458
  • HYR-582
  • GSK212
  • 2,4-Difluoro-N-[2-Methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl]benzenesulfonaMide
  • OMipalisib
  • GSK458
  • Omipalisib (GSK2126458, GSK458)
  • 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide GSK2126458(GSK458)
  • GSK 2126458 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
  • 2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide
  • GSK2126458 (GSK458)
  • GSK2126458, >=98%
  • GSK2126458(Omipalisib)
  • GSK2126458 (GSK458);GSK458;GSK-212; GSK-2126458
  • Omipalisib, 98%, a highly selective and potent inhibitor of PI3K
  • Omipalisib GSK458
  • Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]-
  • GSK-2126458 USP/EP/BP
  • Omipalisib GSK2126458 GSK-2126458
  • 1086062-66-9
  • C25H17F2N5O3S
  • Akt
  • mTOR
  • PI3K
  • Inhibitors
  • PI3K/Akt/mTOR
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds