GSK-2126458

Product Name: GSK-2126458
CAS No.: 1086062-66-9
Chemical Name: GSK-2126458
Synonyms: CS-55;GSK212;GSK458;HYR-582;OMipalisib;GSK2126458;GSK-2126458;GSK2126458, >=98%;Omipalisib GSK458;GSK2126458 (GSK458)
CBNumber: CB92505205
Molecular Formula: C25H17F2N5O3S
Formula Weight: 505.5
MOL File: 1086062-66-9.mol

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GSK-2126458 Property

Melting point:: 187-189℃
Boiling point:: 715.6±70.0 °C(Predicted)
Density: 1.45
storage temp.: Refrigerator
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
form: Solid
pka: 6.23±0.40(Predicted)
color: White to Pale Yellow

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Safety

HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3161
Product name: GSK2126458
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $91.6
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML3161
Product name: GSK2126458
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $369
Updated: 2022/05/15

Cayman Chemical

Product number: 17377
Product name: GSK2126458
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 17377
Product name: GSK2126458
Purity: ≥98%
Packaging: 5mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 17377
Product name: GSK2126458
Purity: ≥98%
Packaging: 10mg
Price: $380
Updated: 2024/03/01

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GSK-2126458 Chemical Properties,Usage,Production

Description

GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (K_is = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (K_is = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells.

Uses

A highly potent inhibitor of PI3K and the mammalian target of Rapamycin.

Definition

ChEBI: Omipalisib is a member of the class of quinolines that is quinoline which is substituted by pyridazin-4-yl and 5-[(2,4-difluorobenzene-1-sulfonyl)amino]-6-methoxypyridin-3-yl groups at positions 4 and 6, respectively. It is a highly potent inhibitor of PI3K and mTOR developed by GlaxoSmithKline and was previously in human phase 1 clinical trials for the treatment of idiopathic pulmonary fibrosis and solid tumors. It has a role as an autophagy inducer, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, a mTOR inhibitor, an antineoplastic agent, a radiosensitizing agent and an anticoronaviral agent. It is a member of quinolines, a difluorobenzene, a sulfonamide, an aromatic ether, a member of pyridines and a member of pyridazines.

target

p110α

storage

Store at -20°C

GSK-2126458 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-2126458 Suppliers

Canada 1 China 143 India 2 United Kingdom 2 United States 19 Global 167

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8012
Advantage: 62

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
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JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
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Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
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ProdList: 479
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Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

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View Lastest Price from GSK-2126458 manufacturers

Career Henan Chemical Co

Product: GSK-2126458 1086062-66-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1086062-66-9, GSK-2126458Related Search:

daprodustat,GSK1278863 GSK1940029 GSK 189254A GSK2110183 gsk2200150a 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% AZD-3965 GSK1292263 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine GSK-3beta Inhibitor XXVI(GSK-3b) Cadmium sulfide AZD-8055 MK-2206 2HCl Pictilisib Erlotinib hydrochloride LY 294002 HYDROCHLORIDE Danirixin

GSK2126458

GSK-2126458

GSK2126458; GSK-2126458

2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide

GSK2126458 (HYR-582)

CS-55

Omipalisib GSK2126458

HYR-582

GSK212

2,4-Difluoro-N-[2-Methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl]benzenesulfonaMide

OMipalisib

GSK458

Omipalisib (GSK2126458, GSK458)

2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide GSK2126458(GSK458)

GSK 2126458 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide

2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide

GSK2126458 (GSK458)

GSK2126458, >=98%

GSK2126458(Omipalisib)

GSK2126458 (GSK458);GSK458;GSK-212; GSK-2126458

Omipalisib, 98%, a highly selective and potent inhibitor of PI3K

Omipalisib GSK458

Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]-

GSK-2126458 USP/EP/BP

Omipalisib GSK2126458 GSK-2126458

1086062-66-9

C25H17F2N5O3S

Akt

mTOR

PI3K

Inhibitors

PI3K/Akt/mTOR

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds