1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
- Product Name
- 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
- CAS No.
- 117690-79-6
- Chemical Name
- 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
- Synonyms
- LY 255283;CGS 23356;5'-Ethyl-2'-hydroxy-4'-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone;1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOLE-5-YL)HEPTYL]OXY]PHENYL]-ETHANONE;parcnchyma,LTB4,Leukotriene Receptor,inhibit,BLT2,LY255283,lung,Inhibitor,LY-255283;1-(5-Ethyl-2-hydroxy-4-((6-methyl-6-(2H-tetrazol-5-yl)heptyl)oxy)phenyl)ethan-1-one;Ethanone, 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(2H-tetrazol-5-yl)heptyl]oxy]phenyl]-
- CBNumber
- CB9257308
- Molecular Formula
- C19H28N4O3
- Formula Weight
- 360.45
- MOL File
- 117690-79-6.mol
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Property
- Melting point:
- 160-162 °C
- Boiling point:
- 573.4±60.0 °C(Predicted)
- Density
- 1.157±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMSO: >20mg/mL
- pka
- 5.11±0.10(Predicted)
- form
- powder
- color
- off-white to light yellow
Safety
- WGK Germany
- 2
N-Bromosuccinimide Price
- Product number
- L1920
- Product name
- LY255283
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- L1920
- Product name
- LY255283
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $634
- Updated
- 2022/05/15
- Product number
- 70715
- Product name
- LY255283
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 70715
- Product name
- LY255283
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $94
- Updated
- 2024/03/01
- Product number
- 70715
- Product name
- LY255283
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2024/03/01
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Chemical Properties,Usage,Production
Description
Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years. The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100 nM. LY255283 exhibits IC50 values of ~950 nM and >10 μM at human recombinant BLT2 and BLT1 receptors, respectively. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 μM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260 nM.
Uses
LY-255283 is a selective, competitive BLT2 receptor antagonist used in the treatment of chronic myeloid leukemia.
Definition
ChEBI: 1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone is an aromatic ketone.
Biological Activity
Selective, competitive antagonist of BLT 2 receptors (IC 50 values are ~ 1 and > 10 μ M at human recombinant BLT 2 and BLT 1 receptors respectively). Inhibits LTB 4 -induced contraction of lung parenchyma (pA 2 = 7.2), and reduces LTB 4 -mediated airway obstruction in guinea pigs following i.v. and oral administration.
storage
Store at +4°C
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Preparation Products And Raw materials
Raw materials
Preparation Products
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Suppliers
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