6-O-Benzylguanine

Product Name: 6-O-Benzylguanine
CAS No.: 19916-73-5
Chemical Name: 6-O-Benzylguanine
Synonyms: 6-benzylguanine;O6-BENZYLGUANINE;O6-Benzylguanine ,98%;6-(benzyloxy)-7H-purin-2-aMine;O6-BenzyL;NSC 637037;6-O-BENZYLGUANINE;6-BENZYLOXY GUANINE;6-oxo -benzylguanine;4 6-Benzyloxyguanine
CBNumber: CB9263934
Molecular Formula: C12H11N5O
Formula Weight: 241.25
MOL File: 19916-73-5.mol

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6-O-Benzylguanine Property

Melting point:: 193(dec.)
Boiling point:: 459.3±55.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: methanol: 20 mg/mL
form: solid
pka: 7.47±0.20(Predicted)
color: Off-White to Light Yellow
CAS DataBase Reference: 19916-73-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B2292
Product name: O6-Benzylguanine
Purity: ≥98% (TLC), solid
Packaging: 50mg
Price: $107
Updated: 2024/03/01

Alfa Aesar

Product number: H60274
Product name: O6-Benzylguanine, 98%
Packaging: 250mg
Price: $47.65
Updated: 2024/03/01

Cayman Chemical

Product number: 16332
Product name: O6-Benzylguanine
Purity: ≥98%
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16332
Product name: O6-Benzylguanine
Purity: ≥98%
Packaging: 1g
Price: $699
Updated: 2024/03/01

Cayman Chemical

Product number: 16332
Product name: O6-Benzylguanine
Purity: ≥98%
Packaging: 50mg
Price: $56
Updated: 2024/03/01

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6-O-Benzylguanine Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.

Uses

O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Biochem/physiol Actions

O6-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer. The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma.

6-O-Benzylguanine Preparation Products And Raw materials

Raw materials

Acetonitrile N,N-Dimethylformamide Guanine Benzyl alcohol Tetraethylammonium Chloride 6-Chloroguanine Toluene Phosphorus oxychloride Ethyl acetate 1,2-Dichloroethane Hydrochloric acid Acetic acid Sodium hydroxide Activated carbon

Preparation Products

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6-O-Benzylguanine Suppliers

Canada 3 China 334 Czech Republic 1 Europe 2 Germany 5 India 12 South Korea 1 Switzerland 2 United Kingdom 11 United States 52 Global 423

Carbosynth

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21Cec PX Pharm. Ltd.

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Apollo Scientific Ltd

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Biosynth Carbosynth

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Key Organics Ltd.

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Apollo Scientific Ltd.

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Sequoia Research Products Ltd.

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Carbosynth Limited

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Leancare Ltd.

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MOLEKULA Ltd.

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Eurolabs Limited

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View Lastest Price from 6-O-Benzylguanine manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 6-O-Benzylguanine 19916-73-5
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5ton
Release date: 2024-04-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 6-O-Benzylguanine 19916-73-5
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kgs
Release date: 2021-10-28

airuikechemical co., ltd.

Product: O6-Benzylguanine 19916-73-5
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 20 tons
Release date: 2024-03-15

19916-73-5, 6-O-BenzylguanineRelated Search:

EC 2.6.1.2 6-Aminocaproic acid 2-Aminopurine Benzyltrimethylammonium chloride 6-Methoxyguanine Benzyl chloride 3-Aminophenol Tris(hydroxymethyl)aminomethane 6-Benzylaminopurine Glycine ALTRENOGEST Purine Guanine Acetaminophen Benzyltriethylammonium chloride 4-Methoxybenzylchloride Iminodibenzyl 6-Thioguanine

O(sup 6)benzylguanidine

O6-Benzylguanine ,98%

2-Amino-6-(benzyloxy)-9H-purine

6-(Benzyloxy)-1H-purin-2-amine

6-(benzyloxy)-7H-purin-2-aMine

6-(PhenylMethoxy)-9H-purin-2-aMine

NSC 637037

6-benzylguanine

6-oxo -benzylguanine

6-O-Benzylguanine(O6BG)

9H-Purin-2-amine,6-(phenylmethoxy)-

6-phenylmethoxy-7H-purin-2-amine

O6-BENZYLGUANINE

2-Amino-6-(benzyloxy)purine

2-amino-6-(phenylmethoxy)-9h-purine

Ganciclovir Impurity 12

6-O-BENZYLGUANINE

6-BENZYLOXY-9H-PURIN-2-AMINE

6-BENZYLOXY GUANINE

4 6-Benzyloxyguanine

6-BENZYLOXY GUANINE2-AMINO-6-BENZYLOXYPURINE

O6-BenzyL

2-((2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)propane-1,3-diyl dibenzoate

"2-Amino-6-(benzyloxy)purine, 2-Amino-6-(phenylmethoxy)-9H-purine"

19916-73-5

9916-73-5

Apoptosis and Cell Cycle

DNA Repair Regulators

DNA metabolism

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Alkylguanine-DNA alkyltransferase, mammalian DNA repair proteinApoptosis and Cell Cycle

DNA Repair Regulators

A to

DNA metabolism

Enzyme Inhibitors by Enzyme

Nucleotides and Nucleosides

Bases & Related Reagents

Nucleotides