ChemicalBook > CAS DataBase List > 6-O-Benzylguanine

6-O-Benzylguanine

Product Name
6-O-Benzylguanine
CAS No.
19916-73-5
Chemical Name
6-O-Benzylguanine
Synonyms
6-benzylguanine;O6-BENZYLGUANINE;O6-Benzylguanine ,98%;6-(benzyloxy)-7H-purin-2-aMine;O6-BenzyL;NSC 637037;6-O-BENZYLGUANINE;6-BENZYLOXY GUANINE;6-oxo -benzylguanine;4 6-Benzyloxyguanine
CBNumber
CB9263934
Molecular Formula
C12H11N5O
Formula Weight
241.25
MOL File
19916-73-5.mol
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6-O-Benzylguanine Property

Melting point:
193(dec.)
Boiling point:
459.3±55.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
methanol: 20 mg/mL
form 
solid
pka
7.47±0.20(Predicted)
color 
Off-White to Light Yellow
CAS DataBase Reference
19916-73-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B2292
Product name
O6-Benzylguanine
Purity
≥98% (TLC), solid
Packaging
50mg
Price
$107
Updated
2024/03/01
Alfa Aesar
Product number
H60274
Product name
O6-Benzylguanine, 98%
Packaging
250mg
Price
$47.65
Updated
2024/03/01
Cayman Chemical
Product number
16332
Product name
O6-Benzylguanine
Purity
≥98%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16332
Product name
O6-Benzylguanine
Purity
≥98%
Packaging
1g
Price
$699
Updated
2024/03/01
Cayman Chemical
Product number
16332
Product name
O6-Benzylguanine
Purity
≥98%
Packaging
50mg
Price
$56
Updated
2024/03/01
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6-O-Benzylguanine Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.

Uses

O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Biochem/physiol Actions

O6-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer. The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma.

6-O-Benzylguanine Preparation Products And Raw materials

Raw materials

Acetonitrile N,N-Dimethylformamide Guanine Benzyl alcohol Tetraethylammonium Chloride 6-Chloroguanine Toluene Phosphorus oxychloride Ethyl acetate 1,2-Dichloroethane Hydrochloric acid Acetic acid Sodium hydroxide Activated carbon

Preparation Products

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6-O-Benzylguanine Suppliers

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View Lastest Price from 6-O-Benzylguanine manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
6-O-Benzylguanine 19916-73-5
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5ton
Release date
2024-04-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
6-O-Benzylguanine 19916-73-5
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kgs
Release date
2021-10-28
airuikechemical co., ltd.
Product
O6-Benzylguanine 19916-73-5
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20 tons
Release date
2024-03-15

19916-73-5, 6-O-BenzylguanineRelated Search:

EC 2.6.1.2 6-Aminocaproic acid 2-Aminopurine Benzyltrimethylammonium chloride 6-Methoxyguanine Benzyl chloride 3-Aminophenol Tris(hydroxymethyl)aminomethane 6-Benzylaminopurine Glycine ALTRENOGEST Purine Guanine Acetaminophen Benzyltriethylammonium chloride 4-Methoxybenzylchloride Iminodibenzyl 6-Thioguanine

  • O(sup 6)benzylguanidine
  • O6-Benzylguanine ,98%
  • 2-Amino-6-(benzyloxy)-9H-purine
  • 6-(Benzyloxy)-1H-purin-2-amine
  • 6-(benzyloxy)-7H-purin-2-aMine
  • 6-(PhenylMethoxy)-9H-purin-2-aMine
  • NSC 637037
  • 6-benzylguanine
  • 6-oxo -benzylguanine
  • 6-O-Benzylguanine(O6BG)
  • 9H-Purin-2-amine,6-(phenylmethoxy)-
  • 6-phenylmethoxy-7H-purin-2-amine
  • O6-BENZYLGUANINE
  • 2-Amino-6-(benzyloxy)purine
  • 2-amino-6-(phenylmethoxy)-9h-purine
  • Ganciclovir Impurity 12
  • 6-O-BENZYLGUANINE
  • 6-BENZYLOXY-9H-PURIN-2-AMINE
  • 6-BENZYLOXY GUANINE
  • 4 6-Benzyloxyguanine
  • 6-BENZYLOXY GUANINE2-AMINO-6-BENZYLOXYPURINE
  • O6-BenzyL
  • 2-((2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)propane-1,3-diyl dibenzoate
  • "2-Amino-6-(benzyloxy)purine, 2-Amino-6-(phenylmethoxy)-9H-purine"
  • 19916-73-5
  • 9916-73-5
  • Apoptosis and Cell Cycle
  • DNA Repair Regulators
  • DNA metabolism
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Alkylguanine-DNA alkyltransferase, mammalian DNA repair proteinApoptosis and Cell Cycle
  • DNA Repair Regulators
  • A to
  • DNA metabolism
  • Enzyme Inhibitors by Enzyme
  • Nucleotides and Nucleosides
  • Bases & Related Reagents
  • Nucleotides