4-PHENOXYPHENYLBORONIC ACID

ChemicalBook > CAS DataBase List > 4-PHENOXYPHENYLBORONIC ACID

4-PHENOXYPHENYLBORONIC ACID

Product Name: 4-PHENOXYPHENYLBORONIC ACID
CAS No.: 51067-38-0
Chemical Name: 4-PHENOXYPHENYLBORONIC ACID
Synonyms: EOS-61617;AKOS BRN-0132;RARECHEM AH PB 0260;TIMTEC-BB SBB003409;Ibrutinib Impurity 36;4-PHENOXYPHENYLBORONI;4-Boronodiphenyl ether;4-phenoxy-phenylboric acid;4-PHENOXYPHENYLBORONIC ACID;4-PHENOXYBENZENEBORONIC ACID
CBNumber: CB9278200
Molecular Formula: C12H11BO3
Formula Weight: 214.02
MOL File: 51067-38-0.mol

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4-PHENOXYPHENYLBORONIC ACID Property

Melting point:: 141-145 °C(lit.)
Boiling point:: 377.0±44.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 8.76±0.10(Predicted)
form: Crystalline Powder
color: White to beige
InChI: InChI=1S/C12H11BO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9,14-15H
InChIKey: KFXUHRXGLWUOJT-UHFFFAOYSA-N
SMILES: B(C1=CC=C(OC2=CC=CC=C2)C=C1)(O)O
CAS DataBase Reference: 51067-38-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 480142
Product name: 4-Phenoxyphenylboronic acid
Purity: ≥95.0%
Packaging: 5g
Price: $49.14
Updated: 2024/03/01

Sigma-Aldrich

Product number: 480142
Product name: 4-Phenoxyphenylboronic acid
Purity: ≥95.0%
Packaging: 25g
Price: $363
Updated: 2023/06/20

TCI Chemical

Product number: P1974
Product name: 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $57
Updated: 2024/03/01

TCI Chemical

Product number: P1974
Product name: 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 25g
Price: $169
Updated: 2024/03/01

Alfa Aesar

Product number: H52950
Product name: 4-Phenoxybenzeneboronic acid, 98%
Packaging: 1g
Price: $31.65
Updated: 2024/03/01

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4-PHENOXYPHENYLBORONIC ACID Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder and chunk

Uses

suzuki reaction

Uses

4-Phenoxybenzeneboronic Acid is an intermediate used to prepare biphenyl derivatives of nitotrifluoromethoxybenzyloxydihydroimidazooxazines with antitubercular activity. It is also used in the synthesis of pyrrolo pyrimidines as potent inhibitors of Lck kinase.

Uses

4-Phenoxyphenylboronic acid can be used as a reactant:

In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst.
To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions.
To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.

Synthesis

4-Bromodiphenyl ether (100 g, 0.402 mol)Was dissolved in anhydrous THF (800 mL)Under nitrogen protection,Cooled to -78 ° C,N-butyllithium (n-BuLi) (177 mL, 0.442 mol)The temperature is kept below -65 ° C,After stirring for 1 h,Continue to maintain the temperature -60 ,Triisopropyl borate (90 g, 0.482 mol) was added dropwise,Slowly rose to 0 ° C, stir for 3 h.Water (300 mL) was added under ice bath overnight. The reaction solution was concentrated to remove the organic phase,With 12N concentrated hydrochloric acid pH adjusted to 1 ~ 2,Precipitation of solids,Filtration and drying gave 4-phenoxyphenylboronic acid (77 g, yield 90%).

4-PHENOXYPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

4-Bromophenoxybenzene Trimethyl borate Tetrahydrofuran n-Butyllithium

Preparation Products

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4-PHENOXYPHENYLBORONIC ACID Suppliers

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View Lastest Price from 4-PHENOXYPHENYLBORONIC ACID manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-PHENOXYPHENYLBORONIC ACID 51067-38-0
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Nanjing Fred Technology Co., Ltd

Product: 4-Phenoxyphenylboronic acid 51067-38-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-28

Hebei Yanxi Chemical Co., Ltd.

Product: 4-PHENOXYPHENYLBORONIC ACID 51067-38-0
Price: US $40.00-40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-06

51067-38-0, 4-PHENOXYPHENYLBORONIC ACIDRelated Search:

4-PHENOXYBENZOIC ACID (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one 4''-PROPYL-3-FLUOROBIPHENYL-4-BORONIC ACID 3,4,5-Trifluorophenylboronic acid 4-Chloro-2-fluoro-3-methoxyphenylboronic acid 4-(Hydroxymethyl)phenylboronic acid 3-Carboxyphenylboronic acid 3-Tolylboronic acid 1-Methyl-4-pyrazole boronic acid pinacol ester Ibrutinib Impurity 24 Ibrutinib (S)-Ibrutinib (S)-3-Hydroxypiperidine Ibrutinib Dimer Impurity Ibrutinib Impurity 28 Ibrutinib Impurity 25 Acrylic anhydride 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine

4-PHENOXYBENZENEBORONIC ACID

4-PHENOXYPHENYLBORONIC ACID

AKOS BRN-0132

RARECHEM AH PB 0260

(P-PHENOXYPHENYL)BORONIC ACID

TIMTEC-BB SBB003409

4-Phenoxybenzeneboronic acid 98%

4-Phenoxyphenylboronic acid,97%

4-Phenoxyphenylboronic acid ,98%

4-Phenoxyphenylboronic Acid (contains varying aMounts of Anhydride)

4-Phenoxyphenylboronic acid, 97% 1GR

EOS-61617

4-Phenoxyphenylboronic acid Ibrutinib

4-Boronodiphenyl ether

4-Phenoxyphenylboronic acid >=95.0%

Ibrutinib Impurity 36

4-Phenoxyphenylboronic acid, 98%, for synthesis

Boronic acid, B-(4-phenoxyphenyl)-

4-PHENOXYPHENYLBORONI

4-phenoxy-phenylboric acid

51067-38-0

C12H11BO3

Aryl

Boronic Acids

Boronic Acids and Derivatives

Organometallic Reagents

blocks

BoronicAcids

Heterocyclic Compounds

Aryl

Organoborons

Boronic Acids

Boronic Acids and Derivatives

Boronic Acids