4-PHENOXYPHENYLBORONIC ACID
- Product Name
- 4-PHENOXYPHENYLBORONIC ACID
- CAS No.
- 51067-38-0
- Chemical Name
- 4-PHENOXYPHENYLBORONIC ACID
- Synonyms
- EOS-61617;AKOS BRN-0132;RARECHEM AH PB 0260;TIMTEC-BB SBB003409;Ibrutinib Impurity 36;4-PHENOXYPHENYLBORONI;4-Boronodiphenyl ether;4-phenoxy-phenylboric acid;4-PHENOXYPHENYLBORONIC ACID;4-PHENOXYBENZENEBORONIC ACID
- CBNumber
- CB9278200
- Molecular Formula
- C12H11BO3
- Formula Weight
- 214.02
- MOL File
- 51067-38-0.mol
4-PHENOXYPHENYLBORONIC ACID Property
- Melting point:
- 141-145 °C(lit.)
- Boiling point:
- 377.0±44.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- 8.76±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to beige
- InChI
- InChI=1S/C12H11BO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9,14-15H
- InChIKey
- KFXUHRXGLWUOJT-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(OC2=CC=CC=C2)C=C1)(O)O
- CAS DataBase Reference
- 51067-38-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 480142
- Product name
- 4-Phenoxyphenylboronic acid
- Purity
- ≥95.0%
- Packaging
- 5g
- Price
- $49.14
- Updated
- 2024/03/01
- Product number
- 480142
- Product name
- 4-Phenoxyphenylboronic acid
- Purity
- ≥95.0%
- Packaging
- 25g
- Price
- $363
- Updated
- 2023/06/20
- Product number
- P1974
- Product name
- 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $57
- Updated
- 2024/03/01
- Product number
- P1974
- Product name
- 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $169
- Updated
- 2024/03/01
- Product number
- H52950
- Product name
- 4-Phenoxybenzeneboronic acid, 98%
- Packaging
- 1g
- Price
- $31.65
- Updated
- 2024/03/01
4-PHENOXYPHENYLBORONIC ACID Chemical Properties,Usage,Production
Chemical Properties
white to off-white powder and chunk
Uses
suzuki reaction
Uses
4-Phenoxybenzeneboronic Acid is an intermediate used to prepare biphenyl derivatives of nitotrifluoromethoxybenzyloxydihydroimidazooxazines with antitubercular activity. It is also used in the synthesis of pyrrolo pyrimidines as potent inhibitors of Lck kinase.
Uses
4-Phenoxyphenylboronic acid can be used as a reactant:
- In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst.
- To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions.
- To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.
Synthesis
4-Bromodiphenyl ether (100 g, 0.402 mol)Was dissolved in anhydrous THF (800 mL)Under nitrogen protection,Cooled to -78 ° C,N-butyllithium (n-BuLi) (177 mL, 0.442 mol)The temperature is kept below -65 ° C,After stirring for 1 h,Continue to maintain the temperature -60 ,Triisopropyl borate (90 g, 0.482 mol) was added dropwise,Slowly rose to 0 ° C, stir for 3 h.Water (300 mL) was added under ice bath overnight. The reaction solution was concentrated to remove the organic phase,With 12N concentrated hydrochloric acid pH adjusted to 1 ~ 2,Precipitation of solids,Filtration and drying gave 4-phenoxyphenylboronic acid (77 g, yield 90%).
4-PHENOXYPHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-PHENOXYPHENYLBORONIC ACID Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28398
- Advantage
- 80
View Lastest Price from 4-PHENOXYPHENYLBORONIC ACID manufacturers
- Product
- 4-PHENOXYPHENYLBORONIC ACID 51067-38-0
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 4-Phenoxyphenylboronic acid 51067-38-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-28
- Product
- 4-PHENOXYPHENYLBORONIC ACID 51067-38-0
- Price
- US $40.00-40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-06