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DBCO-maleimide

Product Name
DBCO-maleimide
CAS No.
1395786-30-7
Chemical Name
DBCO-maleimide
Synonyms
Dibenzocyclooctyne-maleimide;DBCO-MAL;DBCO-maleimide;DBCO-Maleimide,Dibenzocyclooctyne-maleimide;DBCO-maleimide (This product is unavailable in the U.S.);DBCO-maleimide (This product is unavailable in the U.S.) (2mg*5);Dibenzocyclooctyne-maleimide (This product is unavailable in the U.S.);1H-Pyrrole-1-propanamide, N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-2,5-dihydro-2,5-dioxo-;N-[3-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide;N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]-3-(2,5-dioxopyrrol-1-yl)propanamide
CBNumber
CB92985649
Molecular Formula
C25H21N3O4
Formula Weight
427.45
MOL File
1395786-30-7.mol
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DBCO-maleimide Property

Melting point:
162 °C
Boiling point:
790.5±60.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO, DCM, DMF
form 
Solid
pka
15.03±0.46(Predicted)
color 
Off-white to Gray
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Safety

Hazard Codes 
N
Risk Statements 
50
Safety Statements 
61
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
760668
Product name
Dibenzocyclooctyne-maleimide
Purity
for Copper-free Click Chemistry
Packaging
1MG
Price
$32.8
Updated
2023/06/20
Sigma-Aldrich
Product number
760668
Product name
Dibenzocyclooctyne-maleimide
Purity
for Copper-free Click Chemistry
Packaging
5MG
Price
$101
Updated
2023/06/20
Sigma-Aldrich
Product number
760668
Product name
Dibenzocyclooctyne-maleimide
Purity
for Copper-free Click Chemistry
Packaging
50MG
Price
$393
Updated
2023/06/20
TRC
Product number
A939575
Product name
Dbco-Maleimide
Packaging
1mg
Price
$40
Updated
2021/12/16
Chem-Impex
Product number
35063
Product name
DBCOmaleimide,95%(HPLC)
Purity
95%(HPLC)
Packaging
5MG
Price
$56
Updated
2021/12/16
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DBCO-maleimide Chemical Properties,Usage,Production

Description

DBCO-Maleimide is a sulfhydryl reactive reagent containing a maleimide group and a DBCO moiety. Maleimide group specifically and efficiently reacts with thiols to form thioether bonds. The low mass weight will add minimal spacer to modified molecules and will enable simple and efficient incorporation of DBCO moiety into cysteine-containing peptides or other thiol-containing biomolecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Applications Include:

  • Protein-peptide conjugates
  • Antibody-enzyme or antibody-drug conjugates
  • Protein or peptide-oligonucleotide conjugates
  • Surface modification

Uses

Dbco-Maleimide is used in preparation of radioactive metal indicator-chelating peptide derivative-conjugated antibodies for medical imaging.

DBCO-maleimide Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-maleimide Suppliers

TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16684
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
021-58088081 Q3382968513
Fax
QQ3382968513
Email
hailey@shsendpharm.com
Country
China
ProdList
3129
Advantage
55
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
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View Lastest Price from DBCO-maleimide manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
DBCO-Maleimide 1395786-30-7
Price
US $0.00/mg
Min. Order
25mg
Purity
>98.00%
Supply Ability
250
Release date
2024-03-20

1395786-30-7, DBCO-maleimideRelated Search:


  • DBCO-maleimide
  • Dibenzocyclooctyne-maleimide
  • Dibenzocyclooctyne-maleimide (This product is unavailable in the U.S.)
  • 1H-Pyrrole-1-propanamide, N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-2,5-dihydro-2,5-dioxo-
  • DBCO-Maleimide,Dibenzocyclooctyne-maleimide
  • DBCO-maleimide (This product is unavailable in the U.S.)
  • DBCO-maleimide (This product is unavailable in the U.S.) (2mg*5)
  • N-[3-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide
  • DBCO-MAL
  • N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]-3-(2,5-dioxopyrrol-1-yl)propanamide
  • 1395786-30-7
  • ADC LINKER