ChemicalBook > CAS DataBase List > 2-Chloro-4-methyl-3-nitropyridine

2-Chloro-4-methyl-3-nitropyridine

Product Name
2-Chloro-4-methyl-3-nitropyridine
CAS No.
23056-39-5
Chemical Name
2-Chloro-4-methyl-3-nitropyridine
Synonyms
2-Chloro-4-Methyl-3-NP;2-CHLORO-3-NITRO-4-PICOLINE;2-Chloro-3-nitro-4-picoline,98%;2-CHLORO-3-NITRO-4-METHYLPYRIDINE;2-CHLORO-4-METHYL-3-NITROPYRIDINE;3-Nitro-2-chloro-4-methylpyridine;2,Chloro-4-Methyl-3-3-nitropyridine;2-Chloro-4-methyl-3-nitropyridine>PYRIDINE, 2-CHLORO-4-METHYL-3-NITRO-;2-Chloro-4-methyl-3-nitropyridine 98+%
CBNumber
CB9304053
Molecular Formula
C6H5ClN2O2
Formula Weight
172.57
MOL File
23056-39-5.mol
More
Less

2-Chloro-4-methyl-3-nitropyridine Property

Melting point:
51-53 °C (lit.)
Boiling point:
279.6±35.0 °C(Predicted)
Density 
1.406±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
-1.80±0.10(Predicted)
form 
Powder
color 
Yellow to beige
Sensitive 
Hygroscopic
InChI
InChI=1S/C6H5ClN2O2/c1-4-2-3-8-6(7)5(4)9(10)11/h2-3H,1H3
InChIKey
JHARVUVBTAAPLA-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(C)=C1[N+]([O-])=O
CAS DataBase Reference
23056-39-5(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-21/22
Safety Statements 
26-37/39-36/37/39-36
RIDADR 
UN2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333999
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
304360
Product name
2-Chloro-4-methyl-3-nitropyridine
Purity
99%
Packaging
1g
Price
$108
Updated
2023/01/07
TCI Chemical
Product number
C2012
Product name
2-Chloro-4-methyl-3-nitropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
C2012
Product name
2-Chloro-4-methyl-3-nitropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$47
Updated
2025/07/31
TRC
Product number
C369145
Product name
2-Chloro-4-methyl-3-nitropyridine
Packaging
1g
Price
$50
Updated
2021/12/16
TRC
Product number
C369145
Product name
2-Chloro-4-methyl-3-nitropyridine
Packaging
2g
Price
$80
Updated
2021/12/16
More
Less

2-Chloro-4-methyl-3-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

2-Chloro-4-methyl-3-nitropyridine is a cyclopropyldipyridodiazepinone derivative for use as non-nucleoside reverse transcriptase inhibitors.

Definition

2-Chloro-4-methyl-3-nitropyridine (2C4M3NP) is a nitropyridine derivative that could form an acceptor fragment of 2-adamantylamino-5-nitropyridine (AANP). This crystal shows a particularly large optical non-linearity. It is observed that the mean C-C (ring) bond distance calculated between the ring carbon atoms of 2C4M3NP is 1.387 Å. In X-ray data of pyridine, the mean C-C (ring) bond distance is 1.394 Å. The C-H bond distances are found to be 1.081 Å. The computed values of C-C (ring) and C-H are slightly higher than that of the experimental value. This is attributed to the substituents present in the pyridine. The C-C-C bond angle where the -Cl and -NO2 group is attached with the middle carbon is more than 120? while the C-C-C bond angle where the -CH3 is substituted is less than 120? in 2C4M3NP. The N-C-CH3 bond angle (116.3。) is less than that of the C-C-CH3 (124.2。) probably due to the weak hydrogen bond formed between the nitrogen and hydrogen of the methyl group[1].

General Description

Experimental FTIR and FT-Raman spectroscopic analysis of 2-chloro-4-methyl-3-nitropyridine was reported.

Synthesis

21901-18-8

23056-39-5

General procedure for the synthesis of 2-chloro-4-methyl-3-nitropyridine from 2-keto-3-nitro-4-methylpyridine: 2-keto-3-nitro-4-methylpyridine (13 g, 0.084 mol) was added to 50 mL of phosphorochloridic acid chloride and heated to reflux for 4 hours. Upon completion of the reaction, the excess phosphorus trichloride was removed by distillation. The crude product was recrystallized in 50 mL of 75% ethanol solution to give 11 g of white solid product in 75.3% yield. The melting point of the product was 51.7-52.1 °C (ethanol), which is consistent with the values reported in the literature (52.0-52.9 °C) [J.O.C., 1955, 20, 1729-1731].

References

[1] Arjunan, V. , et al. "A comparative study on vibrational, conformational and electronic structure of 2-chloro-4-methyl-3-nitropyridine and 2-chloro-6-methylpyridine." Spectrochimica Acta Part A Molecular & Biomolecular Spectroscopy 92.none(2012):305-317.

2-Chloro-4-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

3-AMINO-2-FLUORO-4-PICOLINE
More
Less

2-Chloro-4-methyl-3-nitropyridine Suppliers

Americas 1 Belgium 1 Canada 1 China 251 Europe 2 France 2 Germany 4 India 50 Japan 2 Jordan 1 South Korea 1 Switzerland 1 United Kingdom 18 United States 51 Global 386
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
21193
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Hestia Laboratories, Inc.
Tel
--
Fax
--
Email
info@hestialabs.com
Country
United States
ProdList
167
Advantage
58
SynQuest Laboratories, Inc.,
Tel
--
Fax
--
Country
United States
ProdList
2301
Advantage
58
Meruvax Pharma (North America)
Tel
--
Fax
--
Country
United States
ProdList
91
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
SLN Pharmachem
Tel
--
Fax
--
Email
slnpharmachem@vsnl.net
Country
United States
ProdList
188
Advantage
43
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Sinova Inc.
Tel
--
Fax
--
Email
sales@sinovainc.com
Country
United States
ProdList
4009
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Small Molecules, Inc.
Tel
--
Fax
--
Email
sales@small-molecules.com
Country
United States
ProdList
1218
Advantage
30
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
Small Molecules, Inc.
Tel
--
Fax
--
Email
sales@small-molecules.com
Country
United States
ProdList
990
Advantage
50
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
ChemContract Research Inc.
Tel
--
Fax
--
Country
United States
ProdList
1526
Advantage
38
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Magical Scientific LLC
Tel
--
Fax
--
Country
United States
ProdList
703
Advantage
0
AstaTech, Inc
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
6371
Advantage
58
NOVASYN ORGANICS PVT LTD
Tel
--
Fax
--
Email
info@novasynorganics.com
Country
United States
ProdList
1316
Advantage
55
Alkali Metals Limited
Tel
--
Fax
--
Country
United States
ProdList
284
Advantage
43
Focus Synthesis LLC
Tel
--
Fax
--
Email
acd@focussynthesis.com
Country
United States
ProdList
2487
Advantage
61
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
VARDA Biotech (P) Ltd.
Tel
--
Fax
--
Email
vijay@vardabiotech.com
Country
United States
ProdList
208
Advantage
66
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
COREY ORGANICS LIMITED
Tel
--
Fax
--
Email
Info@coreyorganics.com
Country
United States
ProdList
126
Advantage
38
Alkalimetals
Tel
--
Fax
--
Email
alkalimetals@alkalimetals.com
Country
United States
ProdList
151
Advantage
66
Magical Scientific LLP
Tel
--
Fax
--
Country
United States
ProdList
750
Advantage
43
Chontech, Inc.
Tel
--
Fax
--
Email
chontech@yahoo.com
Country
United States
ProdList
1101
Advantage
30
ECA International Corporation
Tel
--
Fax
--
Email
services@ecacorporation.com
Country
United States
ProdList
1062
Advantage
52
Atlantic SciTech Group, Inc.
Tel
--
Fax
--
Email
sales@astginc.com
Country
United States
ProdList
2308
Advantage
43
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
Asymchem Laboratories, Inc.
Tel
--
Fax
--
Email
info@asymchem.com
Country
United States
ProdList
1315
Advantage
69
More
Less

View Lastest Price from 2-Chloro-4-methyl-3-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Chloro-4-methyl-3-nitropyridine 23056-39-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-05-29
Henan Fengda Chemical Co., Ltd
Product
2-Chloro-4-methyl-3-nitropyridine 23056-39-5
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Hebei Zhanyao Biotechnology Co. Ltd
Product
2-Chloro-4-methyl-3-nitropyridine 23056-39-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-15

23056-39-5, 2-Chloro-4-methyl-3-nitropyridineRelated Search:

Methyl acrylate 2-Chloro-4-picoline Methyl acetate 4-Methyl-3-nitropyridine Bensulfuron methyl 2-Methyl-3-nitropyridine 3-Nitropyridine Kresoxim-methyl Methylparaben 2-Chloro-4-nitropyridine 2-Bromo-5-nitropyridine Azamethiphos 2,6-Lutidine 2,4,6-Collidine 2-Chloro-3-nitropyridine Methyl propyl carbonate Thiophanate-methyl 2-Chloro-5-chloromethylpyridine

  • 2-Chloro-4-Methyl-3-NP
  • 2-CHLORO-4-METHYL-3-NITROPYRIDINE
  • 2-CHLORO-3-NITRO-4-METHYLPYRIDINE
  • 2-CHLORO-3-NITRO-4-PICOLINE
  • PYRIDINE, 2-CHLORO-4-METHYL-3-NITRO-
  • 2-CHLORO-3-NITRO-4-PICOLINE (2-CHLORO-4-METHYL-3-NITROPYRIDINE)
  • 3-Nitro-2-chloro-4-methylpyridine
  • 2-Chloro-3-nitro-4-picoline,98%
  • 2-Chloro-4-methyl-3-nitropyridine 98+%
  • 2,Chloro-4-Methyl-3-3-nitropyridine
  • 2-Chloro-4-methyl-3-nitropyridine&gt
  • 2-Chloro-4-methyl-3-nitropyridine ISO 9001：2015 REACH
  • 23056-39-5
  • C6H5ClN2O2
  • Pyridines
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Halopyridines
  • Chloropyridines
  • Building Blocks
  • Non-nucleoside Reverse Transcriptase
  • Amines
  • Aromatics
  • Heterocycles
  • Pyridine
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyridine series
  • Heterocyclic Compounds
  • Pyridines
  • Chloropyridines
  • Halopyridines
  • Boronic Acid
  • C6Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Heterocycle-Pyridine series