ChemicalBook > CAS DataBase List > BMS-986020

BMS-986020

Product Name: BMS-986020
CAS No.: 1257213-50-5
Chemical Name: BMS-986020
Synonyms: AM152;CS-2492;BMS-986020;AP-3152 free acid;BMS-986020 ，S3572;BMS-986020 (BMS 986020;BMS-986020, 10 mM in DMSO;BMS-986020;BMS 986020;BMS986020;1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-
CBNumber: CB93070650
Molecular Formula: C29H26N2O5
Formula Weight: 482.53
MOL File: 1257213-50-5.mol

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BMS-986020 Property

Melting point:: 174-180°C
Boiling point:: 664.8±55.0 °C(Predicted)
Density: 1.309±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 4.19±0.20(Predicted)
color: White to Off-White
InChIKey: GQBRZBHEPUQRPL-LJQANCHMSA-N
SMILES: C1(C2=CC=C(C3=CC=C(C4ON=C(C)C=4NC(O[C@@H](C4=CC=CC=C4)C)=O)C=C3)C=C2)(C(O)=O)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22049
Product name: BMS 986020
Purity: ≥98%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22049
Product name: BMS 986020
Purity: ≥98%
Packaging: 1mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 22049
Product name: BMS 986020
Purity: ≥98%
Packaging: 5mg
Price: $153
Updated: 2024/03/01

TRC

Product number: B701320
Product name: BMS-986020
Packaging: 25mg
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BB165375
Product name: BMS 986020
Packaging: 50mg
Price: $319.5
Updated: 2021/12/16

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BMS-986020 Chemical Properties,Usage,Production

Description

BMS 986020 is a potent G protein-coupled lysophosphatidic acid receptor 1 (LPA₁) antagonist with an IC₅₀ value less than 300 nM for human LPA₁ expressing CHO cells. Formulations containing BMS 986020 are being investigated in clinical trials for efficacy in idiopathic pulmonary fibrosis.

Uses

BMS-?986020 is an LPA-1 antagonist which may be used in the inhibition and treatment of bleomycin-induced pulminary fibrosis.

References

[1] PETER T. W. CHENG*. Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases[J]. Journal of Medicinal Chemistry, 2021, 64 21: 15549-15581. DOI: 10.1021/acs.jmedchem.1c01256
[2] VEERESA GUDUDURU . Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 2: Pages 451-456. DOI: 10.1016/j.bmcl.2005.08.096
[3] L. SIVARAMAN . Structure dependence and species sensitivity of in vivo hepatobiliary toxicity with lysophosphatidic acid receptor 1 (LPA1) antagonists[J]. Toxicology and applied pharmacology, 2022, 438: Article 115846. DOI: 10.1016/j.taap.2021.115846
[4] BHAKTA PRASAD GAIRE Ji W C Arjun Sapkota. BMS-986020, a Specific LPA1 Antagonist, Provides Neuroprotection against Ischemic Stroke in Mice.[J]. Antioxidants, 2020, 9 11. DOI: 10.3390/antiox9111097

BMS-986020 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BMS-986020 manufacturers

Career Henan Chemical Co

Product: BMS-986020 1257213-50-5
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

Career Henan Chemical Co

Product: BMS-986020 1257213-50-5
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

1257213-50-5, BMS-986020Related Search:

BMS-852927 XL-652 BMS-986142 BMS 303141 BMS813160 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Insulin-like Growth Factor-1 Receptor Inhibitor PD-L1 inhibitor 1 AC480 (BMS-599626) BMS-986205 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacidsodiumsalt (R)-2-(4'-(4-(((1-(2-chlorophenyl)ethoxy)carbonyl)aMino)-3-Methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetic acid BMS-986278 TC LPA5 4

BMS-986020

CS-2492

(R)-1-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid

BMS-986020;BMS 986020;BMS986020

1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

AM152

Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-

inhibit,idiopathic,AM-152,LPL Receptor,Lysophospholipid Receptor,AM 152,IPF,BMS-986020,fibrosis,pulmonary,BMS 986020,autoradiography,Inhibitor,ARG

AP-3152 free acid

BMS-986020, 10 mM in DMSO

BMS-986020 (BMS 986020

BMS-986020 ，S3572

1257213-50-5

257213-50-5