ChemicalBook > CAS DataBase List > BMS-986020

BMS-986020

Product Name
BMS-986020
CAS No.
1257213-50-5
Chemical Name
BMS-986020
Synonyms
AM152;CS-2492;BMS-986020;AP-3152 free acid;BMS-986020 ，S3572;BMS-986020 (BMS 986020;BMS-986020, 10 mM in DMSO;BMS-986020;BMS 986020;BMS986020;1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-
CBNumber
CB93070650
Molecular Formula
C29H26N2O5
Formula Weight
482.53
MOL File
1257213-50-5.mol
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BMS-986020 Property

Melting point:
174-180°C
Boiling point:
664.8±55.0 °C(Predicted)
Density 
1.309±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
4.19±0.20(Predicted)
color 
White to Off-White
InChIKey
GQBRZBHEPUQRPL-LJQANCHMSA-N
SMILES
C1(C2=CC=C(C3=CC=C(C4ON=C(C)C=4NC(O[C@@H](C4=CC=CC=C4)C)=O)C=C3)C=C2)(C(O)=O)CC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22049
Product name
BMS 986020
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22049
Product name
BMS 986020
Purity
≥98%
Packaging
1mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
22049
Product name
BMS 986020
Purity
≥98%
Packaging
5mg
Price
$153
Updated
2024/03/01
TRC
Product number
B701320
Product name
BMS-​986020
Packaging
25mg
Price
$185
Updated
2021/12/16
ChemScene
Product number
CS-5844
Product name
BMS-986020
Purity
99.53%
Packaging
1mg
Price
$60
Updated
2021/12/16
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BMS-986020 Chemical Properties,Usage,Production

Description

BMS 986020 is a potent G protein-coupled lysophosphatidic acid receptor 1 (LPA1) antagonist with an IC50 value less than 300 nM for human LPA1 expressing CHO cells. Formulations containing BMS 986020 are being investigated in clinical trials for efficacy in idiopathic pulmonary fibrosis.

Uses

BMS-?986020 is an LPA-1 antagonist which may be used in the inhibition and treatment of bleomycin-induced pulminary fibrosis.

References

[1] PETER T. W. CHENG*. Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases[J]. Journal of Medicinal Chemistry, 2021, 64 21: 15549-15581. DOI: 10.1021/acs.jmedchem.1c01256
[2] VEERESA GUDUDURU . Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 2: Pages 451-456. DOI: 10.1016/j.bmcl.2005.08.096
[3] L. SIVARAMAN . Structure dependence and species sensitivity of in vivo hepatobiliary toxicity with lysophosphatidic acid receptor 1 (LPA1) antagonists[J]. Toxicology and applied pharmacology, 2022, 438: Article 115846. DOI: 10.1016/j.taap.2021.115846
[4] BHAKTA PRASAD GAIRE  Ji W C  Arjun Sapkota. BMS-986020, a Specific LPA1 Antagonist, Provides Neuroprotection against Ischemic Stroke in Mice.[J]. Antioxidants, 2020, 9 11. DOI: 10.3390/antiox9111097

BMS-986020 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-986020 Suppliers

China 79 United States 9 Global 88
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Abcam Limited
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
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View Lastest Price from BMS-986020 manufacturers

Career Henan Chemical Co
Product
BMS-986020 1257213-50-5
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10
Career Henan Chemical Co
Product
BMS-986020 1257213-50-5
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10

1257213-50-5, BMS-986020Related Search:

BMS-852927 XL-652 BMS-986142 BMS 303141 BMS813160 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Insulin-like Growth Factor-1 Receptor Inhibitor PD-L1 inhibitor 1 AC480 (BMS-599626) BMS-986205 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacidsodiumsalt (R)-2-(4'-(4-(((1-(2-chlorophenyl)ethoxy)carbonyl)aMino)-3-Methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetic acid BMS-986278 TC LPA5 4

  • BMS-986020
  • CS-2492
  • (R)-1-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid
  • BMS-986020;BMS 986020;BMS986020
  • 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid
  • AM152
  • Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-
  • inhibit,idiopathic,AM-152,LPL Receptor,Lysophospholipid Receptor,AM 152,IPF,BMS-986020,fibrosis,pulmonary,BMS 986020,autoradiography,Inhibitor,ARG
  • AP-3152 free acid
  • BMS-986020, 10 mM in DMSO
  • BMS-986020 (BMS 986020
  • BMS-986020 ，S3572
  • 1257213-50-5
  • 257213-50-5