ChemicalBook > CAS DataBase List > Cereblon Ligand 1

Cereblon Ligand 1

Product Name
Cereblon Ligand 1
CAS No.
1061605-21-7
Chemical Name
Cereblon Ligand 1
Synonyms
2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid;TC E3 5031;Thalidomide-O-COOH;Thalidomide-Acid;Cereblon Ligand 1;Cereblon ligand 3;Thalidomide-4-O-C1-COOH;Thalidomide-4-O-CH2-COOH;Thalidomide-4-hydroxyacetate;Pomalidomide Related Compound 1
CBNumber
CB94666380
Molecular Formula
C15H12N2O7
Formula Weight
332.27
MOL File
1061605-21-7.mol
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Cereblon Ligand 1 Property

Boiling point:
660.5±55.0 °C(Predicted)
Density 
1.606±0.06 g/cm3(Predicted)
solubility 
Soluble in DCM
form 
A crystalline solid
pka
2.95±0.10(Predicted)
color 
White to off-white
InChI
InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)
InChIKey
ZVWIXIGBWIEDFO-UHFFFAOYSA-N
SMILES
C(O)(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21589
Product name
Cereblon Ligand 1
Purity
≥98%
Packaging
10mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
21589
Product name
Cereblon Ligand 1
Purity
≥98%
Packaging
100mg
Price
$475
Updated
2024/03/01
Tocris
Product number
6466
Product name
TCE35031
Purity
≥98%(HPLC)
Packaging
100
Price
$439
Updated
2021/12/16
BroadPharm
Product number
BP-24447
Product name
Thalidomide-Acid
Purity
98%
Packaging
250mg
Price
$540
Updated
2021/12/16
BroadPharm
Product number
BP-24447
Product name
Thalidomide-Acid
Purity
98%
Packaging
500mg
Price
$890
Updated
2021/12/16
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Cereblon Ligand 1 Chemical Properties,Usage,Production

Description

Thalidomide-Acid (Cereblon Ligand 1) is a linker of Thalidomide which is commonly used as a precursor to PROTAC that hijacks cereblon as the E3 ubiquitin ligase component.

Uses

Thalidomide-4-hydroxyacetate (Cereblon Ligand 1) is a proteolysis targeting chimeras which allows for the optical control of protein degradation.

Solubility in organics

DMF: 30 mg/ml
DMSO: 30 mg/ml
PBS (pH 7.2): 1 mg/ml

storage

Store at RT

Cereblon Ligand 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Cereblon Ligand 1 Suppliers

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View Lastest Price from Cereblon Ligand 1 manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Thalidomide-O-COOH 1061605-21-7
Price
US $0.00/mg
Min. Order
10mg
Purity
>95.00%
Supply Ability
10g
Release date
2024-04-01
Henan Aochuang Chemical Co.,Ltd.
Product
Cereblon Ligand 1 1061605-21-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-23
Zhuozhou Wenxi import and Export Co., Ltd
Product
Cereblon Ligand 1 1061605-21-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

1061605-21-7, Cereblon Ligand 1Related Search:

1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- E3 Ligase Ligand-Linker Conjugates 21 E3 Ligase Ligand-Linker Conjugates 19 Thalidomide-O-PEG4-Propargyl Thalidomide-linker 10 Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-PEG4-Boc tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate Thalidomide-linker 13 E3 Ligase Ligand-Linker Conjugates 20 4-Hydroxy ThalidoMide Protein degrader 1 (TFA) (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-

  • Cereblon Ligand 1
  • 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid
  • 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
  • TC E3 5031
  • Thalidomide-O-COOH
  • Cereblon ligand 3
  • Pomalidomide Related Compound 1
  • Thalidomide-Acid
  • Acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
  • 2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetic acid
  • Thalidomide-4-hydroxyacetate
  • Thalidomide-O-COOH(Cereblon ligand 3)
  • Eereblon Ligand 1/E3 ligase Ligand 3
  • Thalidomide-4-O-CH2-COOH
  • inhibit,Ligands for E3 Ligase,ThalidomideOCOOH,Inhibitor,Thalidomide O COOH,Cereblon ligand3,E3 ligase-recruiting Moiety,Cereblon ligand-3
  • 2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetic acid
  • 2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]oxy]acetic Acid
  • 2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid
  • Thalidomide-4-O-C1-COOH
  • 1061605-21-7
  • 81061605-21-7