PROTAC FLT-3 degrader 1

Product Name: PROTAC FLT-3 degrader 1
CAS No.: 2230826-81-8
Chemical Name: PROTAC FLT-3 degrader 1
Synonyms: FLT-3 degrader 1;PROTAC FLT-3 degrader 1;PROTACFLT-3degrader1/FLT3PROTAC;(2S,4R)-1-[(2S)-2-{3-[2-(2-{[4-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}phenyl)-7-thia-2,5-diazatricyclo[6.4.0.02,?]dodeca-1(8),3,5,9,11-pentaen-10-yl]oxy}ethoxy)ethoxy]propanamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
CBNumber: CB95540575
Molecular Formula: C52H61N9O9S2
Formula Weight: 1020.23
MOL File: 2230826-81-8.mol

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PROTAC FLT-3 degrader 1 Property

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 150 mg/mL (147.03 mM; Need ultrasonic)
form: Solid
pka: 12.59±0.70(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0082105
Product name: PROTACFLT-3degrader1
Purity: 98.70%
Packaging: 1mg
Price: $780
Updated: 2021/12/16

ChemScene

Product number: CS-0082105
Product name: PROTACFLT-3degrader1
Purity: 98.70%
Packaging: 5mg
Price: $2000
Updated: 2021/12/16

ChemScene

Product number: CS-0082105
Product name: PROTACFLT-3degrader1
Purity: 98.70%
Packaging: 10mg
Price: $3200
Updated: 2021/12/16

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PROTAC FLT-3 degrader 1 Chemical Properties,Usage,Production

Biological Activity

PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction[1].

References

[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.

PROTAC FLT-3 degrader 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC FLT-3 degrader 1 Suppliers

China 16 United States 1 Global 17

Sichuan Wei Keqi Biological Technology Co., Ltd.

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PROTAC FLT-3 degrader 1

PROTACFLT-3degrader1/FLT3PROTAC

FLT-3 degrader 1

(2S,4R)-1-[(2S)-2-{3-[2-(2-{[4-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}phenyl)-7-thia-2,5-diazatricyclo[6.4.0.02,?]dodeca-1(8),3,5,9,11-pentaen-10-yl]oxy}ethoxy)ethoxy]propanamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

2230826-81-8