Pamidronate disodium salt

Product Name: Pamidronate disodium salt
CAS No.: 57248-88-1
Chemical Name: Pamidronate disodium salt
Synonyms: cgp23339a;PAMIDRONATE;CGP 23339AE;PAMIDRONICDISODIUMSALT;PaMidronate DisodiuM API;Pamidronate disodium salt;Disodium Pamidronate Pamidronate (sodium salt);Disodium Pamidronate Hydrate;Pamidronate disodium hydrate
CBNumber: CB9707409
Molecular Formula: C3H12NNaO7P2
Formula Weight: 259.07
MOL File: 57248-88-1.mol

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Pamidronate disodium salt Property

Melting point:: 300 °C
storage temp.: 2-8°C
solubility: H₂O: 28 mg/mL
form: solid
color: white
Merck: 14,7003
Stability:: Hygroscopic
CAS DataBase Reference: 57248-88-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-48-41-37/38-20/21/22
Safety Statements: 22-26-36/37/39-45
RIDADR: 3077
WGK Germany: 3
RTECS: SZ6525000
HazardClass: IRRITANT
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P2371
Product name: Pamidronate disodium salt hydrate
Purity: ≥95% (NMR), solid
Packaging: 10mg
Price: $133
Updated: 2024/03/01

Sigma-Aldrich

Product number: P2371
Product name: Pamidronate disodium salt hydrate
Purity: ≥95% (NMR), solid
Packaging: 100mg
Price: $616
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP615
Product name: Disodium pamidronate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $259
Updated: 2023/06/20

TCI Chemical

Product number: D3921
Product name: Disodium Pamidronate Hydrate
Purity: >97.0%(T)
Packaging: 100mg
Price: $52
Updated: 2024/03/01

TCI Chemical

Product number: D3921
Product name: Disodium Pamidronate Hydrate
Purity: >97.0%(T)
Packaging: 1g
Price: $302
Updated: 2024/03/01

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Pamidronate disodium salt Chemical Properties,Usage,Production

Description

Disodium pamidronate is a calcium metabolism regulator useful in the treatment of hypercalcemia associated with malignancy. It presumably reduces the bone resorption of calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses include osteoporosis and calcitonin-resistant Paget’s disease.

Chemical Properties

White Crystals

Originator

Henkel (United Kingdom)

Uses

Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis.

Uses

A farnesyl diphosphate synthase inhibitor

Uses

A bisphosphonate antiresorptive agent; bone resorption inhibitor.

Manufacturing Process

For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.

brand name

Aredia (Novartis).

Therapeutic Function

Bone resorption suppressant

Biochem/physiol Actions

Pamidronate disodium?has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.

Veterinary Drugs and Treatments

Pamidronate may be useful in treating hypercalcemia associated with vitamin D-related toxicoses or hypercalcemia of malignancy. There is ongoing research on the use of this drug to determine if it has clinical usefulness in directly treating “micro-metastases” in osteosarcomas.

Pamidronate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Pamidronate disodium salt Suppliers

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View Lastest Price from Pamidronate disodium salt manufacturers

Dideu Industries Group Limited

Product: Pamidronate disodium salt 57248-88-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-28

Zhuozhou Wenxi import and Export Co., Ltd

Product: Pamidronate disodium salt 57248-88-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Pamidronate disodium salt 57248-88-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

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PAMIDRONATE DISODIUM CAS NO.:57248-88-1

Pamidronate disodium salt USP/EP/BP

Disodium PamidronateQ: What is Disodium Pamidronate Q: What is the CAS Number of Disodium Pamidronate Q: What is the storage condition of Disodium Pamidronate Q: What are the applications of Disodium Pamidronate

Sodium (3-amino-1-hydroxypropane-1,1-diyl)bis(hydrogen phosphonate)

57248-88-1

C3H9NNa2O7P2xH2O

C3H9NNa2O7P25H2O

C3H9NO7P22Na

C3H9NO7P2Na2

C3H11NO7P22Na

C3H9NO7P22NaH2O

Enzymes, Inhibitors, and Substrates

Farnesyl diphosphate synthase

BioChemical

Biochemicals and Reagents

Enzyme Inhibitors by Enzyme