RO-31-8220

Description

Product Name: RO-31-8220
CAS No.: 138489-18-6
Chemical Name: RO-31-8220
Synonyms: CS-1132;RO-31-8220;Ro31-8220MsOH;Ro 31-8220 Mesylat;Ro 31-8220/Ro318220;RO-31-8220 USP/EP/BP;BisindolylMaleiMide IX Mesylate;Ro 31-8220 Mesylate, 10 mM in DMSO;BISINDOLYLMALEIMIDE IX, METHANESULFONATE;Ro-31-8220 - CAS 138489-18-6 - Calbiochem
CBNumber: CB9711637
Molecular Formula: C25H23N5O2S
Formula Weight: 457.55
MOL File: 138489-18-6.mol

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RO-31-8220 Property

storage temp.: 2-8°C
solubility: DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM)
DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM)
form: Red solid
color: Red
biological source: synthetic (organic)
Water Solubility: water: 1mg/mL
DMSO: 100mg/mL

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Safety

HS Code: 2933790090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 557520
Product name: Ro-31-8220 - CAS 138489-18-6 - Calbiochem
Purity: A cell-permeable, reversible, competitive, and selective inhibitor of protein kinase C (PKC; IC?? = 10 nM) over CaM kinase II (IC?? = 17 μM) and protein kinase A (IC?? = 900 nM).
Packaging: 500μg
Price: $159
Updated: 2024/03/01

Sigma-Aldrich

Product number: R136
Product name: Ro 31-8220 methanesulfonate salt
Purity: solid
Packaging: 1MG
Price: $201
Updated: 2023/06/20

Sigma-Aldrich

Product number: R136
Product name: Ro 31-8220 methanesulfonate salt
Purity: solid
Packaging: 5MG
Price: $631
Updated: 2023/06/20

Cayman Chemical

Product number: 13334
Product name: Bisindolylmaleimide IX (mesylate)
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 13334
Product name: Bisindolylmaleimide IX (mesylate)
Purity: ≥98%
Packaging: 5mg
Price: $166
Updated: 2024/03/01

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RO-31-8220 Chemical Properties,Usage,Production

Description

Ro 31-8220 mesylate is a potent PKC inhibitor, inhibits PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC with IC50 values of 5, 24, 14, 27, 24 and 23 nM, also inhibits MAPKAP -K1b, MSK1, S6K1 and GSK3β with IC50 of 3, 8, 15, 38 nM.

Uses

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

General Description

Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.

Biochem/physiol Actions

Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.

storage

+4°C

RO-31-8220 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO-31-8220 Suppliers

China 115 Europe 1 India 2 Japan 2 United Kingdom 3 United States 19 Global 142

MedChemexpress LLC

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Cckinase, Inc.

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Aladdin Scientific

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BIOMOL INTERNATIONAL, LP

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View Lastest Price from RO-31-8220 manufacturers

Career Henan Chemical Co

Product: Bisindolylmaleimide IX mesylate 138489-18-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

138489-18-6, RO-31-8220Related Search:

GO 6976 D-ERYTHRO-SPHINGOSINE GO 6983 Nintedanib Dasatinib ABT 263 Ponatinib Ibrutinib GF109203X GANGLIOSIDE GD1A DISODIUM SALT BISINDOLYLMALEIMIDE VII 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione RO-31-8220 1-METHYLINDOLE-3-ACETAMIDE RO-31-8220,RO 31-8220 METHANESULFONATE,RO 31-8220 MESYLATE 3-Isopropenyl-1-methyl-1H-pyrrole RO 31-8220 (BISINDOYLMALEIMIDINE IX)

RO-31-8220

Ro 31-8220 Mesylat

BISINDOLYLMALEIMIDE IX, METHANESULFONATE

3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE

BISINDOLYLMALEIMIDE IX METHANESULPHONATE SALT

BisindolylMaleiMide IX Mesylate

BisindolylMaleiMide IX . Methansulfonate [Ro 31-8220]

Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1)

Ro31-8220MsOH

Ro 31-8220/Ro318220

Ro-31-8220 - CAS 138489-18-6 - Calbiochem

3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl carbamimidothioic acid ester mesylate

RO 31-8220 METHANESULFONATE; BISINDOLYLMALEIMIDE IX MESYLATE;RO318220

CS-1132

Bisindolylmaleimide IX (Ro 31-8220 Mesylate)

RO-31-8220 USP/EP/BP

3-(3-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl carbamimidothioate

Ro 31-8220 mesylate (Bisindolylmaleimide IX), Protein kinase inhibitor

Ro 31-8220 Mesylate, 10 mM in DMSO

138489-18-6

C25H23N5O2SCH4O3S

C25H23N5O2S

C26H27N5O5S2

Smad

TGF-beta

Inhibitors

TGF-beta/Smad

inhibitor