BLEOMYCIN A5 HYDROCHLORIDE

Product Name: BLEOMYCIN A5 HYDROCHLORIDE
CAS No.: 55658-47-4
Chemical Name: BLEOMYCIN A5 HYDROCHLORIDE
Synonyms: BLEOCIN(TM);Bleomycin A5 HCl Salt;BLEOCIN(TM) ANTIBIOTIC;Bleomycin A5 Hydrochlorid;Bleomycin A5 Hydrochloride;Bleomycin A5 Hydrochloride Salt;BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP;BLEOCIN(TM), STREPTOMYCES VERTICILLUS;BLEOCIN(TM), STREPTOMYCES VERTICILLUS, ＞85%;N -[3-(4-Aminobutyl)amino]propyl" hydrochloride
CBNumber: CB9762129
Molecular Formula: C57H90ClN19O21S2
Formula Weight: 1477.03
MOL File: 55658-47-4.mol

More

Less

BLEOMYCIN A5 HYDROCHLORIDE Property

Melting point:: >185°C (dec.)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Pale Yellow
Stability:: Hygroscopic

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 19692
Product name: Bleomycin A5 (hydrochloride)
Purity: ≥85%
Packaging: 1mg
Price: $25
Updated: 2021/12/16

Cayman Chemical

Product number: 19692
Product name: Bleomycin A5 (hydrochloride)
Purity: ≥85%
Packaging: 5mg
Price: $113
Updated: 2021/12/16

Cayman Chemical

Product number: 19692
Product name: Bleomycin A5 (hydrochloride)
Purity: ≥85%
Packaging: 10mg
Price: $200
Updated: 2021/12/16

Cayman Chemical

Product number: 19692
Product name: Bleomycin A5 (hydrochloride)
Purity: ≥85%
Packaging: 25mg
Price: $438
Updated: 2021/12/16

Usbiological

Product number: 257225
Product name: Bleomycin A5 hydrochloride
Packaging: 10mg
Price: $406
Updated: 2021/12/16

More

Less

BLEOMYCIN A5 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Bleomycin A5 Hydrochloride is used as an anti-cancer drug used to combat various forms of carcinoma via activated-apoptosis of cancer cells.

Biological Activity

bleomycin a5 is an anticancer chemotherapeutic that binds dna and induces dna cleavage and strand breaks, it is highly toxic. additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. bleomycin may also inhibit thioredoxin reductase.

in vitro

the ic50 of blm alone to the cells was about 2.63 μg/ml. the ic50 of blm was decreased to 1/3.8 and 1/9.5 of 2.63 μg/ml when used in combination with 2.63 μg/ml and 5 μg/ml w-131 [1]. bleomycin a5 induced the activation of a jnk pathway in a dose-dependent manner. after 24h treatment, bleomycin a5 induced dramatic cell death. dapi nuclear staining assay revealed that pd98059 (10 μm) markedly enhanced bleomycin a5-induced apoptosis [2].

in vivo

in the rats, bleomycin a5 induced pulmonary inflammation and fibrosis, increased the levels of malondialdehyde and tumour necrosis factor-α and enhanced accumulation of collagen in the lungs. rolipram administration significantly attenuated these effects [3].

References

[1]. zhang h q, he n g, xue s b. effect of bleomycin a5 with calmodulin inhibitor on the proliferation of s-180 cells in vitro[j]. zhongguo yao li xue bao= acta pharmacologica sinica, 1990, 11(5): 470-473.
[2]. yang l c, yang s h, tai k w, et al. mek inhibition enhances bleomycin a5‐induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities[j]. journal of oral pathology & medicine, 2004, 33(1): 37-45.
[3]. pan j b, hou y h, zhang g j. rolipram attenuates bleomycin a5‐induced pulmonary fibrosis in rats[j]. respirology, 2009, 14(7): 975-982.

BLEOMYCIN A5 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

BLEOMYCIN A5 HYDROCHLORIDE Suppliers

Canada 1 China 85 India 2 United Kingdom 1 United States 8 Global 97

Jilin Aodong Pharmaceutical Group Yanji Co., Ltd.

Tel: 0433-2910159
Email: bgs0159@163.com
Country: China
ProdList: 7
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4550
Advantage: 62

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9552
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

Eastbang Pharmaceuticals Technology Co., Ltd.

Tel: +86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
Fax: +86 (20) 39218032
Country: China
ProdList: 454
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4951
Advantage: 58

Taizhou KEDE Chemical Co., Ltd

Tel: 0576-84613060 13093829633
Fax: 0576-84613060
Email: sales@kedechemical.com
Country: China
ProdList: 298
Advantage: 60

More

Less

View Lastest Price from BLEOMYCIN A5 HYDROCHLORIDE manufacturers

Dideu Industries Group Limited

Product: BLEOMYCIN A5 HYDROCHLORIDE 55658-47-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-01

Shaanxi Dideu Medichem Co. Ltd

Product: BleoMycin A5 Hydrochloride 55658-47-4
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

Career Henan Chemical Co

Product: BLEOMYCIN A5 HYDROCHLORIDE 55658-47-4
Price: US $1.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: G/KG/T
Release date: 2019-12-23

55658-47-4, BLEOMYCIN A5 HYDROCHLORIDERelated Search:

N-BUTYLISOCYANIDE METHYL ISOCYANOACETATE Tosylmethyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE TERT-BUTYL ISOCYANIDE Ferric acetylacetonate BLEOMYCIN A5 HYDROCHLORIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Aluminum acetylacetonate COBALT(II) ACETYLACETONATE Ethyl isocyanoacetate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tris(2,4-pentanedionato)chroMiuM(III) SALCOMINE Benzyl isocyanide Cupric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)

BLEOCIN(TM), STREPTOMYCES VERTICILLUS, ＞85%

Bleomycin A5 Hydrochloride

BleoMycin A5 Hydrochloride(PingyangMycin hydrochloride)

Bleomycin A5 Hydrochlorid

Bleomycin A5 Hydrochloride Salt

n(sup1)-(3-((4-aminobutyl)amino)propyl)bleomycinamidehydrochloride

n(sup1)-(3-((4-aminobutyl)amino)propyl)-bleomycinamidhydrochloride

BLEOCIN(TM)

BLEOCIN(TM) ANTIBIOTIC

BLEOCIN(TM), STREPTOMYCES VERTICILLUS

N -[3-(4-Aminobutyl)amino]propyl" hydrochloride

N1-[3-[(4-Aminobutyl)amino]propyl]bleomycinamide hydrochloride

Bleomycin A5 HCl Salt

BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP

55658-47-4

C57H89N19O21S2xHCl