ChemicalBook > CAS DataBase List > BLEOMYCIN A5 HYDROCHLORIDE

BLEOMYCIN A5 HYDROCHLORIDE

Product Name
BLEOMYCIN A5 HYDROCHLORIDE
CAS No.
55658-47-4
Chemical Name
BLEOMYCIN A5 HYDROCHLORIDE
Synonyms
BLEOCIN(TM);Bleomycin A5 HCl Salt;BLEOCIN(TM) ANTIBIOTIC;Bleomycin A5 Hydrochlorid;Bleomycin A5 Hydrochloride;Bleomycin A5 Hydrochloride Salt;BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP;BLEOCIN(TM), STREPTOMYCES VERTICILLUS;BLEOCIN(TM), STREPTOMYCES VERTICILLUS, ＞85%;N -[3-(4-Aminobutyl)amino]propyl" hydrochloride
CBNumber
CB9762129
Molecular Formula
C57H90ClN19O21S2
Formula Weight
1477.03
MOL File
55658-47-4.mol
More
Less

BLEOMYCIN A5 HYDROCHLORIDE Property

Melting point:
>185°C (dec.)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Pale Yellow
Stability:
Hygroscopic
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
19692
Product name
Bleomycin A5 (hydrochloride)
Purity
≥85%
Packaging
1mg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
19692
Product name
Bleomycin A5 (hydrochloride)
Purity
≥85%
Packaging
5mg
Price
$113
Updated
2021/12/16
Cayman Chemical
Product number
19692
Product name
Bleomycin A5 (hydrochloride)
Purity
≥85%
Packaging
10mg
Price
$200
Updated
2021/12/16
Cayman Chemical
Product number
19692
Product name
Bleomycin A5 (hydrochloride)
Purity
≥85%
Packaging
25mg
Price
$438
Updated
2021/12/16
Usbiological
Product number
257225
Product name
Bleomycin A5 hydrochloride
Packaging
10mg
Price
$406
Updated
2021/12/16
More
Less

BLEOMYCIN A5 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Bleomycin A5 Hydrochloride is used as an anti-cancer drug used to combat various forms of carcinoma via activated-apoptosis of cancer cells.

Biological Activity

bleomycin a5 is an anticancer chemotherapeutic that binds dna and induces dna cleavage and strand breaks, it is highly toxic. additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. bleomycin may also inhibit thioredoxin reductase.

in vitro

the ic50 of blm alone to the cells was about 2.63 μg/ml. the ic50 of blm was decreased to 1/3.8 and 1/9.5 of 2.63 μg/ml when used in combination with 2.63 μg/ml and 5 μg/ml w-131 [1]. bleomycin a5 induced the activation of a jnk pathway in a dose-dependent manner. after 24h treatment, bleomycin a5 induced dramatic cell death. dapi nuclear staining assay revealed that pd98059 (10 μm) markedly enhanced bleomycin a5-induced apoptosis [2].

in vivo

in the rats, bleomycin a5 induced pulmonary inflammation and fibrosis, increased the levels of malondialdehyde and tumour necrosis factor-α and enhanced accumulation of collagen in the lungs. rolipram administration significantly attenuated these effects [3].

References

[1]. zhang h q, he n g, xue s b. effect of bleomycin a5 with calmodulin inhibitor on the proliferation of s-180 cells in vitro[j]. zhongguo yao li xue bao= acta pharmacologica sinica, 1990, 11(5): 470-473.
[2]. yang l c, yang s h, tai k w, et al. mek inhibition enhances bleomycin a5‐induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities[j]. journal of oral pathology & medicine, 2004, 33(1): 37-45.
[3]. pan j b, hou y h, zhang g j. rolipram attenuates bleomycin a5‐induced pulmonary fibrosis in rats[j]. respirology, 2009, 14(7): 975-982.

BLEOMYCIN A5 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BLEOMYCIN A5 HYDROCHLORIDE Suppliers

Canada 1 China 87 India 2 United Kingdom 1 United States 8 Global 99
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
More
Less

View Lastest Price from BLEOMYCIN A5 HYDROCHLORIDE manufacturers

Dideu Industries Group Limited
Product
BLEOMYCIN A5 HYDROCHLORIDE 55658-47-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01
Shaanxi Dideu Medichem Co. Ltd
Product
BleoMycin A5 Hydrochloride 55658-47-4
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30
Career Henan Chemical Co
Product
BLEOMYCIN A5 HYDROCHLORIDE 55658-47-4
Price
US $1.00/g
Min. Order
1g
Purity
98%min
Supply Ability
G/KG/T
Release date
2019-12-23

55658-47-4, BLEOMYCIN A5 HYDROCHLORIDERelated Search:

N-BUTYLISOCYANIDE METHYL ISOCYANOACETATE Tosylmethyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE TERT-BUTYL ISOCYANIDE Ferric acetylacetonate BLEOMYCIN A5 HYDROCHLORIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Aluminum acetylacetonate COBALT(II) ACETYLACETONATE Ethyl isocyanoacetate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tris(2,4-pentanedionato)chroMiuM(III) SALCOMINE Benzyl isocyanide Cupric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)

  • BLEOCIN(TM), STREPTOMYCES VERTICILLUS, ＞85%
  • Bleomycin A5 Hydrochloride
  • BleoMycin A5 Hydrochloride(PingyangMycin hydrochloride)
  • Bleomycin A5 Hydrochlorid
  • Bleomycin A5 Hydrochloride Salt
  • n(sup1)-(3-((4-aminobutyl)amino)propyl)bleomycinamidehydrochloride
  • n(sup1)-(3-((4-aminobutyl)amino)propyl)-bleomycinamidhydrochloride
  • BLEOCIN(TM)
  • BLEOCIN(TM) ANTIBIOTIC
  • BLEOCIN(TM), STREPTOMYCES VERTICILLUS
  • N -[3-(4-Aminobutyl)amino]propyl" hydrochloride
  • N1-[3-[(4-Aminobutyl)amino]propyl]bleomycinamide hydrochloride
  • Bleomycin A5 HCl Salt
  • BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP
  • 55658-47-4
  • C57H89N19O21S2xHCl