BLEOMYCIN A5 HYDROCHLORIDE

ChemicalBook > CAS DataBase List > BLEOMYCIN A5 HYDROCHLORIDE

BLEOMYCIN A5 HYDROCHLORIDE

Product Name: BLEOMYCIN A5 HYDROCHLORIDE
CAS No.: 55658-47-4
Chemical Name: BLEOMYCIN A5 HYDROCHLORIDE
Synonyms: BLEOCIN(TM);Bleomycin A5 HCl Salt;BLEOCIN(TM) ANTIBIOTIC;Bleomycin A5 Hydrochlorid;Bleomycin A5 Hydrochloride;Bleomycin A5 Hydrochloride Salt;BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP;BLEOCIN(TM), STREPTOMYCES VERTICILLUS;BLEOCIN(TM), STREPTOMYCES VERTICILLUS, ＞85%;N -[3-(4-Aminobutyl)amino]propyl" hydrochloride
CBNumber: CB9762129
Molecular Formula: C57H90ClN19O21S2
Formula Weight: 1477.03
MOL File: 55658-47-4.mol

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BLEOMYCIN A5 HYDROCHLORIDE Property

Melting point:: >185°C (dec.)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Pale Yellow
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19692
Product name: Bleomycin A5 (hydrochloride)
Purity: ≥85%
Packaging: 1mg
Price: $25
Updated: 2021/12/16

Cayman Chemical

Product number: 19692
Product name: Bleomycin A5 (hydrochloride)
Purity: ≥85%
Packaging: 5mg
Price: $113
Updated: 2021/12/16

Cayman Chemical

Product number: 19692
Product name: Bleomycin A5 (hydrochloride)
Purity: ≥85%
Packaging: 10mg
Price: $200
Updated: 2021/12/16

Cayman Chemical

Product number: 19692
Product name: Bleomycin A5 (hydrochloride)
Purity: ≥85%
Packaging: 25mg
Price: $438
Updated: 2021/12/16

TRC

Product number: B595750
Product name: BleomycinA5HydrochlorideSalt
Packaging: 1mg
Price: $120
Updated: 2021/12/16

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BLEOMYCIN A5 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Bleomycin A5 Hydrochloride is used as an anti-cancer drug used to combat various forms of carcinoma via activated-apoptosis of cancer cells.

Biological Activity

bleomycin a5 is an anticancer chemotherapeutic that binds dna and induces dna cleavage and strand breaks, it is highly toxic. additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. bleomycin may also inhibit thioredoxin reductase.

in vitro

the ic50 of blm alone to the cells was about 2.63 μg/ml. the ic50 of blm was decreased to 1/3.8 and 1/9.5 of 2.63 μg/ml when used in combination with 2.63 μg/ml and 5 μg/ml w-131 [1]. bleomycin a5 induced the activation of a jnk pathway in a dose-dependent manner. after 24h treatment, bleomycin a5 induced dramatic cell death. dapi nuclear staining assay revealed that pd98059 (10 μm) markedly enhanced bleomycin a5-induced apoptosis [2].

in vivo

in the rats, bleomycin a5 induced pulmonary inflammation and fibrosis, increased the levels of malondialdehyde and tumour necrosis factor-α and enhanced accumulation of collagen in the lungs. rolipram administration significantly attenuated these effects [3].

References

[1]. zhang h q, he n g, xue s b. effect of bleomycin a5 with calmodulin inhibitor on the proliferation of s-180 cells in vitro[j]. zhongguo yao li xue bao= acta pharmacologica sinica, 1990, 11(5): 470-473.
[2]. yang l c, yang s h, tai k w, et al. mek inhibition enhances bleomycin a5‐induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities[j]. journal of oral pathology & medicine, 2004, 33(1): 37-45.
[3]. pan j b, hou y h, zhang g j. rolipram attenuates bleomycin a5‐induced pulmonary fibrosis in rats[j]. respirology, 2009, 14(7): 975-982.

BLEOMYCIN A5 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BLEOMYCIN A5 HYDROCHLORIDE manufacturers

Dideu Industries Group Limited

Product: BLEOMYCIN A5 HYDROCHLORIDE 55658-47-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-01

Shaanxi Dideu Medichem Co. Ltd

Product: BleoMycin A5 Hydrochloride 55658-47-4
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

Career Henan Chemical Co

Product: BLEOMYCIN A5 HYDROCHLORIDE 55658-47-4
Price: US $1.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: G/KG/T
Release date: 2019-12-23

55658-47-4, BLEOMYCIN A5 HYDROCHLORIDERelated Search:

N-BUTYLISOCYANIDE METHYL ISOCYANOACETATE Tosylmethyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE TERT-BUTYL ISOCYANIDE Ferric acetylacetonate BLEOMYCIN A5 HYDROCHLORIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Aluminum acetylacetonate COBALT(II) ACETYLACETONATE Ethyl isocyanoacetate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tris(2,4-pentanedionato)chroMiuM(III) SALCOMINE Benzyl isocyanide Cupric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)

BLEOCIN(TM), STREPTOMYCES VERTICILLUS, ＞85%

Bleomycin A5 Hydrochloride

BleoMycin A5 Hydrochloride(PingyangMycin hydrochloride)

Bleomycin A5 Hydrochlorid

Bleomycin A5 Hydrochloride Salt

n(sup1)-(3-((4-aminobutyl)amino)propyl)bleomycinamidehydrochloride

n(sup1)-(3-((4-aminobutyl)amino)propyl)-bleomycinamidhydrochloride

BLEOCIN(TM)

BLEOCIN(TM) ANTIBIOTIC

BLEOCIN(TM), STREPTOMYCES VERTICILLUS

N -[3-(4-Aminobutyl)amino]propyl" hydrochloride

N1-[3-[(4-Aminobutyl)amino]propyl]bleomycinamide hydrochloride

Bleomycin A5 HCl Salt

BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP

55658-47-4

C57H89N19O21S2xHCl