4,6-Dichloro-5-pyrimidinecarbaldehyde

Product Name: 4,6-Dichloro-5-pyrimidinecarbaldehyde
CAS No.: 5305-40-8
Chemical Name: 4,6-Dichloro-5-pyrimidinecarbaldehyde
Synonyms: ASISCHEM C51985;TIMTEC-BB SBB005606;4,6-Dichloro-5-formylpyrimidine;6-DichloropyriMidine-5-carboxaldehyde;4,6-DICHLORO-5-PYRIMIDINECARBALDEHYDE;4,6-DICHLORO-PYRIMIDINE-5-CARBALDEHYDE;4,6-Dichloro-5-pyrimidine formaldehyde;5-PyriMidinecarbaldehyde, 4,6-dichloro-;4,6-Dichloropyrimidine-5-carboxaldehyde;4,6-DICHLORO-5-PYRIMIDINE CARBOXALDEHYDE
CBNumber: CB9784321
Molecular Formula: C5H2Cl2N2O
Formula Weight: 176.99
MOL File: 5305-40-8.mol

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4,6-Dichloro-5-pyrimidinecarbaldehyde Property

Melting point:: 66-71 °C
Boiling point:: 92-93 °C(Press: 0.05 Torr)
Density: 1.588±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -5.90±0.26(Predicted)
form: solid
color: Yellow
InChI: InChI=1S/C5H2Cl2N2O/c6-4-3(1-10)5(7)9-2-8-4/h1-2H
InChIKey: XQSJHQXYQAUDFC-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C(C=O)C(Cl)=N1
CAS DataBase Reference: 5305-40-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-43-36/38-22
Safety Statements: 26-36-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 638145
Product name: 4,6-Dichloropyrimidine-5-carboxaldehyde
Purity: 97%
Packaging: 1g
Price: $32.7
Updated: 2023/06/20

TRC

Product number: D438353
Product name: 4,6-Dichloropyrimidine-5-carbaldehyde
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 043714
Product name: 4,6-Dichloro-5-pyrimidinecarbaldehyde
Purity: >95%
Packaging: 25g
Price: $84
Updated: 2021/12/16

AK Scientific

Product number: R605
Product name: 4,6-Dichloropyrimidine-5-carbaldehyde
Packaging: 25g
Price: $114
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK110173
Product name: 4,6-Dichloro-5-pyrimidinecarbaldehyde
Purity: 96%
Packaging: 1g
Price: $121
Updated: 2021/12/16

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4,6-Dichloro-5-pyrimidinecarbaldehyde Chemical Properties,Usage,Production

Chemical Properties

White to off-white solid

Uses

4,6-Dichloropyrimidine-5-carboxaldehyde is used as a substrate in the synthesis of N-terminal surrogate in amino acid and peptide analogues.

Synthesis

68-12-2

1193-24-4

5305-40-8

General procedure for the synthesis of 4,6-dichloro-5-pyrimidinecarboxaldehyde from N,N-dimethylformamide (DMF) and 4,6-dihydroxypyrimidine: First, DMF (64 mL) was mixed with phosphorus oxychloride (POCl3) (200 mL) and stirred for 1 hr at 0 °C. Subsequently, 4,6-dihydroxypyrimidine (50.0 g, 446 mmol) was added to the mixture and stirring was continued for 0.5 h at room temperature. Next, the resulting non-homogeneous mixture was heated to reflux for 3 hours. After completion of the reaction, the volatiles were removed by distillation under reduced pressure and the residue was carefully poured into ice water. The aqueous phase was extracted six times with ether and the organic phases were combined. The organic phase was washed sequentially with aqueous sodium bicarbonate (NaHCO3) and pure water and dried over anhydrous sodium sulfate (Na2SO4). The dried organic phase was concentrated under reduced pressure and finally crystallized by ethyl acetate (EtOAc)-petroleum ether mixed solvent to afford the target product 4,6-dichloro-5-pyrimidinecarboxaldehyde (43.5 g, 55% yield). The product was analyzed by LC-MS (ESI), m/z 177 [M+H]+.

References

[1] Patent: US2006/281700, 2006, A1. Location in patent: Page/Page column 34
[2] Patent: US2006/281755, 2006, A1. Location in patent: Page/Page column 40
[3] Patent: US2006/281764, 2006, A1. Location in patent: Page/Page column 25
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 16, p. 3353 - 3358
[5] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 12, p. 2936 - 2941

4,6-Dichloro-5-pyrimidinecarbaldehyde Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 4,6-Dihydroxypyrimidine Phosphorus oxitrichloride Diethyl ether

Preparation Products

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4,6-Dichloro-5-pyrimidinecarbaldehyde Suppliers

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View Lastest Price from 4,6-Dichloro-5-pyrimidinecarbaldehyde manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 4,6-Dichloro-5-pyrimidinecarbaldehyde 5305-40-8
Price: US $60.00-600.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-13

Henan Fengda Chemical Co., Ltd

Product: 4,6-Dichloro-5-pyrimidinecarbaldehyde 5305-40-8
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 4,6-Dichloro-5-pyrimidinecarbaldehyde 5305-40-8
Price: US $18.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-24

5305-40-8, 4,6-Dichloro-5-pyrimidinecarbaldehydeRelated Search:

4,6-Dichloropyrimidine Sulfadiazine Sodium dichloroisocyanurate Dichloroethane 4,6-Dichloro-5-fluoropyrimidine Thionyl chloride 2,4,6-TRICHLORO-PYRIMIDINE-5-CARBALDEHYDE 4,6-DICHLORO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Pyrimidine-5-carboxaldehyde 4,6-dichloropyrimidine-5-carboxylic acid (4,6-Dichloropyrimidin-5-yl)(quinolin-4-yl)methanone 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 5-Pyrimidinecarbonyl chloride, 4,6-dichloro- (9CI) (4,6-Dichloropyrimidin-5-yl)(4-methoxy-2-(trifluoromethyl)phenyl)methanone 5-PYRIMIDINECARBOXYLIC ACID, 4,6-DICHLORO-,METHYL ESTER 4,6-DICHLORO-5-PYRIMIDINECARBOXAMIDE

4,6-Dichloro-5-formylpyrimidine

4,6-DICHLOROPYRIMIDINE-5-CARBALDEHYDE,PURITY:97% MIN(HPLC)

6-DichloropyriMidine-5-carboxaldehyde

5-PyriMidinecarbaldehyde, 4,6-dichloro-

4,6-Dichloro-5-pyrimidinecarbaldehyde ,96%

5-PyriMidinecarboxaldehyde, 4,6-dichloro-

4,6-Dichloro-5-formylpyrimidine, 4,6-Dichloro-5-formyl-1,3-diazine

4,6-Dichloropyrimidine-5-carboxaldehyde,97%

4,6-Dichloro-5-pyrimidinecarbaldehyde 4,6-Dichloropyrimidine-5-carboxaldehyde

TIMTEC-BB SBB005606

4,6-DICHLORO-PYRIMIDINE-5-CARBALDEHYDE

4,6-DICHLORO-5-PYRIMIDINECARBALDEHYDE

4,6-DICHLORO-5-PYRIMIDINE CARBOXALDEHYDE

ASISCHEM C51985

4,6-Dichloropyrimidine-5-carboxaldehyde

4,6-Dichloropyrimidine-5-carboxaldehyde 97%

4,6-Dichloro-5-pyrimidinecarbaldehyde ISO 9001：2015 REACH

4,6-Dichloro-5-pyrimidine formaldehyde

5305-40-8

C5H2Cl2N2O

C5H2N2OCl2

Heterocycle-Pyrimidine series

Pyrimidine series

Carbonyl Compounds

Heterocycles

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

PyrimidinesHeterocyclic Building Blocks

Pyrimidine