2-Chloropyridine Property

Melting point:

-46 °C

Boiling point:

166 °C/714 mmHg (lit.)

Density 

1.2 g/mL at 25 °C (lit.)

vapor pressure 

1.7 mm Hg ( 20 °C)

refractive index 

n20/D 1.532(lit.)

Flash point:

149 °F

storage temp. 

Refrigerator

solubility 

27g/l

form 

Liquid

pka

0.49(at 25℃)

color 

Clear colorless to light yellow

PH

6-7 (27g/l, H2O, 20℃)

Water Solubility 

27 g/L (20 ºC)

BRN 

105788

CAS DataBase Reference

109-09-1(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 2-chloro-(109-09-1)

EPA Substance Registry System

2-Chloropyridine (109-09-1)

Safety

Hazard Codes 

T

Risk Statements 

23/24/25-36/37/38

Safety Statements 

26-36/37/39-45-28A-27

RIDADR 

UN 2822 6.1/PG 2

WGK Germany 

3

RTECS 

US5950000

Hazard Note 

Toxic

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29333999

Hazardous Substances Data

109-09-1(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

2-Chloropyridine Chemical Properties,Usage,Production

Chemical Properties

Clear colourless to light yellow liquid

Uses

2- Chloropyridine is used as an intermediate chemical in the production of various pyrithione, for use in cosmetics, personal care products and pharmaceutical products.

Uses

2-Chloropyridine (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during t he decomposition of specific insecticides.

Definition

ChEBI: 2-chloropyridine is a monochloropyridine.

Synthesis Reference(s)

Synthetic Communications, 19, p. 897, 1989 DOI: 10.1080/00397918908051009
Synthesis, p. 337, 1990

General Description

A colorless oily liquid. Toxic by ingestion and/or skin absorption. Used to make other chemicals.

Air & Water Reactions

Slightly soluble in water and denser than water.

Hazard

Toxic by ingestion.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Poison by ingestion, inhalation, skin contact, and intraperitoneal routes. Combustible when exposed to heat or flame. Can react with oxidizing materials. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and phosgene.

Purification Methods

Dry 2-chloropyridine with NaOH for several days, then distil it from CaO under reduced pressure. [Beilstein 20/5 V 402.]