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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Chemical Name:
Canagliflozin Impurity 24
Chemical Name:
Carfilzomib Impurity 5
Structure:
Chemical Name:
Dolutegravir Impurity 6
CAS:
1357289-29-2
MF:
C20H19F2N3O5
Chemical Name:
Febuxostat Impurity 22
Chemical Name:
Istradefylline Impurity C
Structure:
Chemical Name:
Everolimus O-Ethyl Impurity
CAS:
1704711-12-5
MF:
C54H85NO14
Structure:
Chemical Name:
(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-1-methyl-4-phenylpiperidine
CAS:
324023-99-6
MF:
C20H23NO3
Structure:
Chemical Name:
Solifenacin Impurity 4(Solifenacin EP Impurity H)
CAS:
732228-02-3
MF:
C23H26N2O2
Structure:
Chemical Name:
849217-77-2
CAS:
849217-77-2
MF:
C22H20N2O6
Structure:
Chemical Name:
1-Piperidinepropanoic acid, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, ethyl ester, (3R,4R)-
CAS:
1675248-18-6
MF:
C18H25N5O3
Structure:
Chemical Name:
Amlodipine iMpurity L
CAS:
1821498-25-2
MF:
C17H19ClN2O5
Structure:
Chemical Name:
(6R,7R)-7-[(2,2-dimethylpropanoyl)amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS:
2384108-14-7
MF:
C16H20N4O4S3
Structure:
Chemical Name:
methyl (41R,12R,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
CAS:
58000-63-8
MF:
C21H26N2O3
Structure:
Chemical Name:
N-(4-Hydroxymethylbenzyl) Cyclam
CAS:
176252-20-3
MF:
C18H32N4O
Chemical Name:
Alvimopan Impurity 3
Chemical Name:
Nicergoline Impurity G
Structure:
Chemical Name:
Isavuconazole Impurity 1
CAS:
2069200-13-9
MF:
C13H12F2N4O
Chemical Name:
Sofosbuvir Impurity23
Structure:
Chemical Name:
4-BROMOMETHYLBIPHEBYL-2'-CARBOXYLIC ACID
CAS:
150766-86-2
MF:
C14H11BrO2
Structure:
Chemical Name:
(R)-2-(((1-(3-(2-cyano-5-fluorobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)amino)methyl)-4-fluorobenzonitrile
MF:
C26H24F2N6O2
Structure:
Chemical Name:
Rosuvastatin Calcium Impurity
CAS:
2514620-36-9
MF:
C22H28FN3O6S
Chemical Name:
Canagliflozin Monoacetyl Impurity
Structure:
Chemical Name:
tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
CAS:
1651214-74-2
MF:
C29H37N7O4
Structure:
Chemical Name:
Prasugrel Impurity 4 HCl
CAS:
1618107-96-2
MF:
C20H22Cl2FNO3S
Chemical Name:
Tofacitinib Impurity K
Structure:
Chemical Name:
N-(3-chloro-4-fluorophenyl)-7 -methoxy-6-(3-morpholinopropoxy)-N-(3-morpholinopropyl)quinazolin-4-amine
CAS:
1502829-45-9
MF:
C29H37ClFN5O4
Structure:
Chemical Name:
5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one
CAS:
24021-90-7
MF:
C3H5N3O2
Structure:
Chemical Name:
( 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butylester )
CAS:
475084-96-9
MF:
C29H37N3O3
Chemical Name:
Tacrolimus Impurity 1
Structure:
Chemical Name:
Bisoprolol EP Impurity F
CAS:
1798418-82-2
MF:
C18H31NO4
Structure:
Chemical Name:
Pantoprazole EP Impurity F
CAS:
721924-06-7
MF:
C17H17F2N3O4S
Chemical Name:
Rosuvastatin EP Impurity E
Structure:
Chemical Name:
Tiotropium EP Impurity C
CAS:
136310-95-7
MF:
C19H22BrNO3S2
Structure:
Chemical Name:
Eliglustat intermediate 4
CAS:
491833-27-3
MF:
C23H30N2O4
Structure:
Chemical Name:
2-[(4-Acetylphenyl)methyl]cyclopentan-1-one
CAS:
96824-28-1
MF:
C14H16O2
Structure:
Chemical Name:
Dapoxetine Impurity 1
CAS:
119357-22-1
MF:
C22H25NO
Chemical Name:
Mirabegron Impurity 5
Chemical Name:
Milrinone Impurity 5
Structure:
Chemical Name:
Solifenacin Related Compound 20
CAS:
1300713-32-9
MF:
C17H17NO
Structure:
Chemical Name:
Cefuroxime Impurity 2
MF:
C16H16N4O8S
Chemical Name:
Cefoxitin Impurity 1
Structure:
Chemical Name:
Mupirocin iMpurity B
MF:
C26H44O9
Chemical Name:
Nicorandil Impurity 2
Chemical Name:
Piperacillin Impurity 7
Structure:
Chemical Name:
Defluoro Paroxetine Hydrochloride
CAS:
1394842-91-1
Chemical Name:
Afatinib Impurity 15
Structure:
Chemical Name:
Milnacipran Impurity 11
CAS:
1410831-12-7
MF:
C11H10O2
Chemical Name:
Mirabegron Impurity 18
Structure:
Chemical Name:
Atorvastatin lactone
CAS:
125995-03-1
MF:
C33H33FN2O4
Structure:
Chemical Name:
Prucalopride Impurity F
CAS:
1900715-98-1
MF:
C18H26ClN3O4
Structure:
Chemical Name:
tert-butyl (R)-3-(hydroxymethyl)hexanoate
CAS:
1928755-17-2
MF:
C11H22O3
Structure:
Chemical Name:
Alfuzosin
CAS:
19216-53-6
MF:
C12H16N4O2
Structure:
Chemical Name:
4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-ethoxy-6-[(1-methyl-2-pyrrolidinylidene)amino]-3-quinolinecarbonitrile
CAS:
1144516-21-1
MF:
C29H27ClN6O2
Chemical Name:
Sofosbuvir Impurity 5
Structure:
Chemical Name:
Ondansetron impurity G (PhEur)
CAS:
99614-04-7
MF:
C17H18ClN3O
Structure:
Chemical Name:
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
CAS:
1421312-34-6
MF:
C18H15NO4
Structure:
Chemical Name:
2-[(4-METHYLPHENOXY)METHYL]BENZOIC ACID
CAS:
728-97-2
MF:
C15H14O3
Structure:
Chemical Name:
Ethyl (1R,2R,3S,4R,5S)-4-acetamido-5-amino-2-azido-3- (1-ethylpropoxy)cyclohexanecarboxylate
CAS:
2124269-41-4
MF:
C16H29N5O4
Structure:
Chemical Name:
2-AMINO-3,5-DIBROMOBENZENE-1-CARBOHYDRAZIDE
CAS:
97096-13-4
MF:
C7H7Br2N3O
Structure:
Chemical Name:
Trityl losartan
CAS:
133909-99-6
MF:
C41H37ClN6O
Chemical Name:
Letrozole Impurity
Structure:
Chemical Name:
Alogliptin Impurity C
CAS:
1108731-49-2
MF:
C20H23N5O3
Chemical Name:
Parecoxib Impurity J
Structure:
Chemical Name:
6-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)-1-(4-(2-oxo-1,2-dihydroquinolin-7-yloxy)butyl)quinolin-2(1H)-one
MF:
C38H40N4O4S
Chemical Name:
Atracurium Impurity F
Chemical Name:
Linagliptin Impurity J
Chemical Name:
Linagliptin Impurity Q
Structure:
Chemical Name:
Etoricoxib Impurity 13
CAS:
1817735-82-2
MF:
C25H20ClN3O3S
Structure:
Chemical Name:
Mirabegron Impurity 11
CAS:
1684452-85-4
MF:
C21H24N4O2S
Chemical Name:
Riociguat Impurtiy 2
Structure:
Chemical Name:
Topiroxostat Impurity 9
CAS:
577778-82-6
MF:
C13H8N6O
Chemical Name:
Vonoprazan Impurity F
Structure:
Chemical Name:
Vortioxetine Impurity 15
CAS:
2099147-02-9
MF:
C28H34N4S2
Chemical Name:
Dapagliflozin Impurity H
Chemical Name:
Dapoxetine Impurity C
Chemical Name:
Eltrombopag Impurity 4
Chemical Name:
Iodixanol Impurity
Structure:
Chemical Name:
Levothyroxine EP Impurity B
CAS:
1628720-66-0
MF:
C15H11ClI3NO4
Chemical Name:
Ribavirin Imp. EP)
Structure:
Chemical Name:
Sertraline EP Impurity
MF:
C17H17Cl2N
Structure:
Chemical Name:
Vildagliptin Related Compound G
CAS:
1616662-84-0
MF:
C12H20N4O3
Structure:
Chemical Name:
3-ethyl 5-isopropyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS:
158151-92-9
MF:
C22H29ClN2O5
Structure:
Chemical Name:
Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate
CAS:
1234321-81-3
MF:
C13H12F3NO3
Structure:
Chemical Name:
Cycloastragenol-6-O-β-D-glucoside
CAS:
86764-12-7
MF:
C36H60O10
Structure:
Chemical Name:
FG-4592 intermediate 8
CAS:
1509958-20-6
MF:
C20H17NO6
Chemical Name:
Parecoxib Sodium Imp.E
Chemical Name:
Trelagliptin Impurity 7
Structure:
Chemical Name:
erythro-Guaiacylglycerol β-sinapyl ether 7-O-glucoside
CAS:
412029-03-9
MF:
C27H36O13
Chemical Name:
Cefazolin Impurity 1
Structure:
Chemical Name:
Umeclidinium Bromide Impurity 8
CAS:
869113-10-0
MF:
C27H30BrNO
Chemical Name:
Nifuratel impurity E
Structure:
Chemical Name:
Valsartan Impurity 14
MF:
C24H29N5O3
Chemical Name:
Istradefylline Impurity 4
Chemical Name:
Zolmitriptan Impurity 2
Structure:
Chemical Name:
Atazanavir Impurity 6
CAS:
1006868-81-0
MF:
C32H42N4O5
Structure:
Chemical Name:
Palbociclib Impurity 9
CAS:
2204368-66-9
MF:
C24H29N7O2
Structure:
Chemical Name:
Solifenacin Impurity 1
CAS:
1353274-25-5
MF:
C19H21NO2
Chemical Name:
Vildagliptin Methyl Ester
Chemical Name:
Flucloxacillin Impurity B
Chemical Name:
Ropinirole impurity