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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Chemical Name:
Penicillin Impurity C
Chemical Name:
Cefminox Sodium impurity C
Chemical Name:
Cefotiam Impurity C
Structure:
Chemical Name:
Dequalinium EP Impurity B
CAS:
747387-02-6
MF:
C30H40N4+2
Chemical Name:
Peramivir Impurity F
Structure:
Chemical Name:
4-(1,3,2-Dioxaborinan-2-yl)benzonitrile
CAS:
152846-62-3
MF:
C10H10BNO2
Structure:
Chemical Name:
Rasagiline Impurity 5 Mesylate
CAS:
1312077-04-5
MF:
C13H15NO4S
Structure:
Chemical Name:
MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)
CAS:
80047-24-1
MF:
C12H11N3O2
Structure:
Chemical Name:
3-Anilino-2-(3,4,5-triMethoxybenzyl)acrylonitrile, (Mixture of cis/trans isoMers)
CAS:
30078-48-9
MF:
C19H20N2O3
Structure:
Chemical Name:
Anastrozole EP Impurity I
CAS:
120511-91-3
MF:
C15H17ClN2
Structure:
Chemical Name:
(2R,5S)-5-(3,4-Dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic Acid (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl Ester
CAS:
389128-28-3
MF:
C18H26N2O5S
Chemical Name:
Everolimus impurity F
Chemical Name:
Ceftriaxone Sodium impurity 4
Chemical Name:
Sugammadex sodium Hepta-Iodine Impurity
Chemical Name:
Abitrone project impurity
Structure:
Chemical Name:
105981-34-8
CAS:
105981-34-8
MF:
C15H22N4S
Structure:
Chemical Name:
1364671-52-2
CAS:
1364671-52-2
MF:
C19H19ClN6O3S
Structure:
Chemical Name:
1627504-43-1
CAS:
1627504-43-1
MF:
C14H14ClN7
Chemical Name:
Pramipexole Impurity Q
Structure:
Chemical Name:
Aprepitant Impurity 42
CAS:
172678-47-6
MF:
C20H18F7NO2
Structure:
Chemical Name:
Efinaconazole Related Impurity 13
CAS:
2055912-03-1
MF:
C24H32FN5O
Chemical Name:
DexMedetoMidine IMpurity 17
Structure:
Chemical Name:
Sofosbuvir IMpurity 21
CAS:
2138483-01-7
MF:
C17H17FN2O6
Chemical Name:
Moxifloxacin Impurity 1
Chemical Name:
Moxifloxacin Impurity 22
Chemical Name:
Linagliptin Impurity F
Chemical Name:
Trelagliptin Impurity 4
Chemical Name:
Fudosteine Impurity 1
Structure:
Chemical Name:
Sugammadex Impurity 17
CAS:
2414905-36-3
MF:
C82H120NaO48PS7
Chemical Name:
Apixaban Impurity 28
CAS:
2208275-54-9
Structure:
Chemical Name:
Fluvastatin EP Impurity E
MF:
C24H26FNO4
Chemical Name:
Oseltamivir Impurity 24
Structure:
Chemical Name:
(3S,3'S,4R,4'R)-diphenyl 3,3'-(oxybis(methylene))bis(4-(4- fluorophenyl)piperidine-1-carboxylate)
MF:
C38H38F2N2O5
Chemical Name:
Nettopitan impurity
Structure:
Chemical Name:
Afatinib Impurity 74
CAS:
1259015-90-1
MF:
C7H13NO2
Chemical Name:
Afatinib Impurity 78
Structure:
Chemical Name:
Cabozantinib Impurity 47
CAS:
113136-79-1
MF:
C11H10ClNO3
Chemical Name:
Landiolol impurity Q
Chemical Name:
Tenofovir Impurity 72
Structure:
Chemical Name:
Medetomidine Impurity 52
CAS:
128366-51-8
MF:
C13H14N2O2
Structure:
Chemical Name:
1,2-Benzenediol, 4-(1-hydroxyethyl)-
CAS:
37491-94-4
MF:
C8H10O3
Structure:
Chemical Name:
Acetamide, 2-(diethylamino)-N-(3,4-dimethylphenyl)-
CAS:
3213-16-9
MF:
C14H22N2O
Structure:
Chemical Name:
(trans)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4'-fluoro-[1,1'- biphenyl]-4-yl)piperidine
CAS:
1217975-87-5
MF:
C25H24FNO3
Chemical Name:
Carboprost Impurity 1
Chemical Name:
Beraprost Impurity 1
Chemical Name:
Dofetilide Impurity A
Chemical Name:
Sugammadex disulfide Impurity
Structure:
Chemical Name:
Hispidulin 4'-O-β-D-glucopyranoside
CAS:
244285-12-9
MF:
C22H22O11
Chemical Name:
Dexmedetomidine Impurity 19
Structure:
Chemical Name:
Voriconazole Impurity 18
CAS:
321588-94-7
MF:
C22H18ClF4N7O
Structure:
Chemical Name:
Remdesivir impurity
CAS:
1911578-74-9
MF:
C12H14N5O7P
Structure:
Chemical Name:
ethyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan- 4-yl)acetate
CAS:
616201-27-5
MF:
C38H43FN2O5
Chemical Name:
Peramivir Impurity 16
Structure:
Chemical Name:
Tiotropium bromide Impurity 13
CAS:
1459721-06-2
MF:
C18H19NO4S2
Chemical Name:
Apremilast Impurity TNB
Chemical Name:
Atracurium Impurity N
Chemical Name:
Avibactam Impurity X
Chemical Name:
Cefazolin Impurity L
Chemical Name:
Ceftazidime hetero trans oxidation Impurity
Chemical Name:
Regorafenib Impurity 17
Chemical Name:
Ropivacaine Impurity 45
CAS:
2726971-51-1
Structure:
Chemical Name:
Sildenafil Impurity 17
MF:
C22H30N6O4S
Chemical Name:
Sugammadex sodium Org199074-1 Impurity
Chemical Name:
Sugammadex sodium Org238832-1 Impurity
Chemical Name:
Afatinib impurity 33
Structure:
Chemical Name:
Benzenebutanoic acid, β-amino-2,5-difluoro-, (βR)-
CAS:
936630-56-7
MF:
C10H11F2NO2
Structure:
Chemical Name:
Cyclopropanecarboxylic acid, 1-[[(2-fluorophenyl)amino]carbonyl]-
CAS:
918642-61-2
MF:
C11H10FNO3
Chemical Name:
Isavuconazole Impurity 34
Chemical Name:
Org246653-1(RRT0.31)
Chemical Name:
Linagliptin impurity
Structure:
Chemical Name:
CEFMETAZOLE IMPURITY
CAS:
76952-82-4
MF:
C13H16N6O5S3
Chemical Name:
Acyclovir impurity R
Structure:
Chemical Name:
Ornidazole Impurity 7
CAS:
109620-80-6
MF:
C6H8ClN3O3
Chemical Name:
(1R,2S,5aS,6aS,7aR,8aS,10aS)
Chemical Name:
(E)-8-(3,4-dihydroxystyryl)
Chemical Name:
N,N'-((2Z,2'Z)-disulfanediylbis
Structure:
Chemical Name:
Cabozantinib impurity 1DYH
CAS:
1621681-63-7
MF:
C28H24FN3O6
Structure:
Chemical Name:
1-((2R,3R)-3-(2,3-dihydrobenzo[b]
CAS:
2137145-62-9
MF:
C23H36N2O5
Structure:
Chemical Name:
Tiotropium Bromide Impurity 1
CAS:
2109037-83-2
MF:
C18H20ClNO4S2
Chemical Name:
Anastrozole Impurity I
Chemical Name:
Fluconazole impurity I(For Chinese Pharmacopiea)
Structure:
Chemical Name:
Rocuronium bromide diepoxide impurity
MF:
C21H30O4
Chemical Name:
2-hydroxy-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzonitrile
Structure:
Chemical Name:
6-Methoxykaempferol 3-O-glucoside
CAS:
63422-27-5
MF:
C22H22O12
Chemical Name:
Topiroxostat Impurity 39
Chemical Name:
Vonoprazan Impurity 60
Chemical Name:
PREDNICARBATE IMPURITY F
Structure:
Chemical Name:
2-Propanol, 1,1'-[methylenebis(4,1-phenyleneoxy)]bis[3-[(1-methylethyl)amino]-
CAS:
1225195-70-9
MF:
C25H38N2O4
Structure:
Chemical Name:
INDEX NAME NOT YET ASSIGNED
CAS:
2031272-32-7
MF:
C47H40N4O4
Structure:
Chemical Name:
(4R,5S,6S)-3-[[(3S,5S)-1-[(4-Aminophenyl)methyl]-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Sodium Salt
CAS:
866186-66-5
MF:
C29H33N4NaO7S
Structure:
Chemical Name:
(R)-cis-5ξ-Methyl Atracurium Dibesylate
CAS:
1193104-82-3
MF:
C60H79N2O15S+
Chemical Name:
2-(((Z)-(1-(2-Aminothiazol-4-yl)-2-(((2R,3R)-2-methyl-4-oxo-1-sulfoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic Acid
MF:
C13H17N5O8S2
Structure:
Chemical Name:
7-[4-[2-[[[4-(3-Carboxy-6-fluoro-1-methyl-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinolin-7-yl)-1-piperazinyl]carbonyl]oxy]-3-oxobutyl]-1-piperazinyl]-6-fluoro-1-methyl-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
CAS:
156834-58-1
MF:
C37H36F2N6O9S2
Structure:
Chemical Name:
(6R,7S)-7-ACCA
CAS:
108260-07-7
MF:
C7H7ClN2O3S
Structure:
Chemical Name:
Enrofloxacin Impurity 1
CAS:
1128234-60-5
MF:
C19H22ClN3O3
Chemical Name:
Peramivir Impurity 20
Structure:
Chemical Name:
Ambroxol Impurity 33
CAS:
199472-91-8
MF:
C13H20N2O
Structure:
Chemical Name:
Bilastine Impurity 12
CAS:
1638785-18-8
MF:
C30H42N4O3
Structure:
Chemical Name:
Tadalafil Impurity 66
CAS:
1598416-07-9
MF:
C21H18N2O5
Chemical Name:
Peramivir Impurity 36