HigenaMine Hydrochloride
HigenaMine Hydrochloride Basic information
- Product Name:
- HigenaMine Hydrochloride
- Synonyms:
-
- Demethyl
- 1,2,3,4-Tetrahydro-1-((4-hydroxyphenyl)methyl)-6,7-isoquinolinediol hydrochloride
- Higenamine hydrochloride
- Dacacine base acid and alkali salt
- 6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline
- 6,7-Dihydroxy-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
- 6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1)
- 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrochloride
- CAS:
- 11041-94-4
- MF:
- C16H18ClNO3
- MW:
- 307.77
- EINECS:
- 1592732-453-0
- Product Categories:
-
- 11041-94-4
- Mol File:
- 11041-94-4.mol
HigenaMine Hydrochloride Chemical Properties
- storage temp.
- 4°C, protect from light
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Pale Beige to Pale Brown
- Stability:
- Hygroscopic
HigenaMine Hydrochloride Usage And Synthesis
Toxicity
The safety of orally administered higenamine hydrochloride in humans is unknown. During a study of acute toxicity, mice were orally administered the compound at a dose of 2 g per kg of bodyweight. No mice died during the study.In human trials of intravenous higenamine, subjects who received higenamine reported shortness of breath, racing heart, dizziness, headaches, chest tightness.
Description
Higenamine is a chemical found in several plants including aconite, Annona squamosa, Nandina domestica (sacred bamboo), and others. HigenaMine Hydrochloride is the hydrochloride form of higenamine.
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Linderae odorata.
Uses
Higenamine HCl (norcoclaurine) is a plant-based alkaloid widely used as nutritional supplement in food and beverage industries.
in vivo
Higenamine hydrochloride (10 mg/kg; Intraperitoneal injection; Single dose) can significantly reduce the inflammation and infarct size of cerebral ischemic injury caused by middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats[2].
Higenamine hydrochloride (0.5-4.5 mg/kg; Single dose) improves cardiac and renal function in rats with cardio-renal syndrome (CRS) and alleviates cardiac and renal fibrosis by targeting ASK1/MAPK (ERK, P38)/NF-kB signaling pathway in Sprague-Dawley rats[4].
Higenamine hydrochloride (20 mg/kg-30 mg/kg; Intraperitoneal injection; Once daily for 60 days) promotes bone formation and prevents accelerated bone loss in SAMP6 mice[6].
| Animal Model: | Spontaneous osteoporosis SAMP6 mice model[6] |
| Dosage: | 10 mg/kg, 20 mg/kg |
| Administration: | Intraperitoneal injection (i.p.);Once daily for 60 days |
| Result: | Significantly increased the expression of P1NP and OCN (P1NP and OCN are markers of bone formation). |
IC 50
β adrenergic receptor; ASK1
HigenaMine HydrochlorideSupplier
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