Corynoxine B
Corynoxine B Basic information
- Product Name:
- Corynoxine B
- Synonyms:
-
- Corynoxine B, 99.5%
- Corynoxine B
- 7-Isocorynoxine
- (7R,16E)-17-Methoxy-2-oxo-20betaH-corynox-16-en-16-carbonsae
- Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'R,6'S,7'S,8'aS)-
- Corynoxine B-RM
- (E)-methyl 2-((1'R,6'S,7'S,8a'S)-6'-ethyl-2-oxo-3',5',6',7',8',8a'-hexahydro-2'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate
- CAS:
- 17391-18-3
- MF:
- C22H28N2O4
- MW:
- 384.48
- Mol File:
- 17391-18-3.mol
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Corynoxine B Chemical Properties
- Boiling point:
- 560.8±50.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 83.33 mg/mL (216.74 mM)
- form
- Solid
- pka
- 13.61±0.60(Predicted)
- color
- White to off-white
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Corynoxine B Usage And Synthesis
Chemical Properties
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the Rubiaceae plant Uncaria rhynchophylla.
Uses
Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer.
Definition
ChEBI: Corynoxine B is a member of indolizines. It has a role as a metabolite.
in vivo
Corynoxine B (5-20 mg/kg, i.p.) enhances autophagy of alpha synuclein (alpha syn) clearance in Parkinson's disease mice by targeting HMGB1/2[3].
| Animal Model: | A53T α-syn transgenic mouse model[3]. |
| Dosage: | 5-20 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Promoted α-syn clearance |
IC 50
α-synuclein Aggregation
Corynoxine BSupplier
Nanjing Chemlin Chemical Co., Ltd
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Chengdu Biopurify Phytochemicals Ltd.
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Haoyuan Chemexpress Co., Ltd.
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- 021-58950125
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Shanghai Tauto Biotech Co., Ltd.
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- 021-51320588
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