5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER Chemical Properties

Boiling point:

263℃

Density 

1.439

Flash point:

113℃

storage temp. 

Inert atmosphere,Room Temperature

form 

Solid

pka

1.66±0.20(Predicted)

color 

Pale yellow

Water Solubility 

Slightly soluble in water.

InChI

InChI=1S/C9H10BrNO2/c1-3-13-9(12)8-4-7(10)5-11-6(8)2/h4-5H,3H2,1-2H3

InChIKey

QVKPPFGWQMCQCI-UHFFFAOYSA-N

SMILES

C1(C)=NC=C(Br)C=C1C(OCC)=O

CAS DataBase Reference

129477-21-0

Safety Information

Safety Statements 

24/25

HS Code 

29333990

5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER Usage And Synthesis

Uses

Ethyl 5-bromo-2-methylnicotinate is used as a pharmaceutical intermediate.

Synthesis

To a 250 mL triple-necked flask were added sequentially 4. 9 g of methyl 5-bromo-2-methylnicotinate ( 0. 04 mol), anhydrous ethanol 40 mL, the corresponding amount of concentrated sulfuric acid, and phase transfer catalyst; a stirrer and a distillation apparatus were installed separately. Heat with stirring, gradually increase the temperature, evaporate the ethanol to the required liquid temperature, stop heating, natural cooling, about . 50?? C. It is poured out, and the reactants are white solids at room temperature. Neutralize the product with saturated aqueous sodium carbonate to a pH of about 7 (some solid sodium carbonate may be added if the volume is too large) and extract with 20 of chloroform. mL of chloroform, the combined organic layers were transferred to a reduced-pressure distillation flask, the chloroform was recovered at atmospheric pressure and then ethyl 5-bromo-2-methylnicotinate was distilled at reduced pressure, and the 92- to fraction was collected at 1. 06 kPa. The fraction was collected at 1.06 kPa from 92 to , weighed and the yield was calculated.

5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER(129477-21-0)Related Product Information

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