Basic information Safety Supplier Related

MPEG5-NHS

Basic information Safety Supplier Related

MPEG5-NHS Basic information

Product Name:
MPEG5-NHS
Synonyms:
  • MPEG5-NHS
  • 4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester
  • m-PEG6-NHS ester
  • mPEG5-CH2CH2COONHS Ester
  • mPEG6-NHS
  • Methyl-PEG5-NHS ester
  • mPEG5-SPA
  • mPEG5-CH2CH2COONHS/4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester
CAS:
1449390-12-8
MF:
C18H31NO10
MW:
421.44
Product Categories:
  • mPEG
Mol File:
1449390-12-8.mol
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MPEG5-NHS Chemical Properties

Boiling point:
502.6±60.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
solubility 
Soluble in DMSO, DCM, DMF
form 
Liquid
color 
Colorless to light yellow
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MPEG5-NHS Usage And Synthesis

Description

m-PEG6-NHS ester is a PEG linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media.

Biological Activity

MPEG5-NHS is a non-cleavable 6-unit PEG-containing ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG/Alkyl/ether class, which can be used to synthesize PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs

Alkyl/ether

Non-cleavable

MPEG5-NHSSupplier

Daicel Chiral Technologies (China)CO.,LTD
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021-50460086-9 15921403865
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han_yajun@dctc.daicel.com
ChemPep, Inc.
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+1 (888) 615-9178 / (561) 791-8787
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service@chempep.com
T&W GROUP
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021-61551611 13296011611
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contact@trustwe.com
Nanjing Norris-Pharm Technology Co., Ltd
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13901585132
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799750417@qq.com
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Email
viola@huatengsci.com