TCO-carbonate Chemical Properties

Melting point:

90-105°C

Boiling point:

369.1±45.0 °C(Predicted)

Density 

1.27±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO

form 

Solid

color 

White to off-white

InChI

InChI=1S/C13H17NO5/c15-11-8-9-12(16)14(11)19-13(17)18-10-6-4-2-1-3-5-7-10/h1-2,10H,3-9H2/b2-1+

InChIKey

OUGQJOKGFAIFAQ-OWOJBTEDSA-N

SMILES

C(ON1C(=O)CCC1=O)(=O)OC1CCCC=CCC1 |t:16|

Safety Information

WGK Germany 

3

TCO-carbonate Usage And Synthesis

Description

TCO-NHS Ester is an popular reagent to label amine-containing compound or biomolecule, TCOI enable fast click chemistry with tetrazine.

Uses

Succinimidyl carbonate/NHS functionalized cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.

TCO-carbonate(1191901-33-3)Related Product Information

• TCO-PNB Ester
• (4E)-TCO-PEG4-amine
• TCO-PEG3-Amine
• TCO/E- active ester (p-NPE) / equatorial
• (4E)-TCO-PEG3-amine
• (2E)-TCO-PNB ester
• TCO-PEG4-NHS ester
• (4E)-TCO-PEG4-DBCO
• (4E)-TCO-amine
• TCO-PEG4-Acid
• BDP FL-PEG4-(4E)-TCO
• trans-Cyclooctene-maleimide
• Sulfo-Cy5-(4E)-TCO
• TCO*-PEG2-NH2
• TCO*-PEG4-NHS
• TCO*-PEG8-COOH
• TCO*-PEG2-Maleimide
• TCO*-PEG7-NH2