4-Chloroanisole Chemical Properties

Melting point:

-18 °C (lit.)

Boiling point:

198-202 °C (lit.)

Density 

1.164 g/mL at 25 °C (lit.)

vapor pressure 

1.08hPa at 25℃

refractive index 

n20/D 1.535(lit.)

Flash point:

173 °F

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

color 

Clear colorless to yellow

Water Solubility 

immiscible

BRN 

1858901

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents.

LogP

2.78 at 25℃

CAS DataBase Reference

623-12-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-chloro-4-methoxy-(623-12-1)

EPA Substance Registry System

Benzene, 1-chloro-4-methoxy- (623-12-1)

Safety Information

Hazard Codes 

Xn

Safety Statements 

23-24/25

RIDADR 

UN 2810

WGK Germany 

3

TSCA 

Yes

HS Code 

29093090

MSDS

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4-Chloroanisole Usage And Synthesis

Chemical Properties

colourless liquid

Uses

4-Chloroanisole was found to react with Cu (II)-smectite forming a blue clay-organic complex. 4-Chloroanisole was chosen as the main test substrate for the optimisation studies as it is electronically deactivated and thus resistant to oxidative addition and consequently very reluctant to enter a catalytic manifold.

Synthesis Reference(s)

Chemistry Letters, 16, p. 1901, 1987
The Journal of Organic Chemistry, 35, p. 528, 1970 DOI: 10.1021/jo00827a060

General Description

4-Chloroanisole is an electron-rich chloroarene. It undergoes Ullmann-type homocoupling catalyzed by in situ generated Pd colloids. Reaction of 4-chloroanisole with Cu(II)-smectite in n-hexane, carbon tetrachloride or dichloromethane has been studied. The nucleophilic photosubstitution reactions, photocyanation and photohydrolysis of 4-chloroanisole has been studied by time resolved spectroscopy.

Purification Methods

Wash the anisole with 10% (by volume) aqueous H2SO4 (three times), 10% aqueous KOH (three times), and then with water until neutral. Dry it (MgSO4), and fractionally distil it from CaH2 through a glass helices-packed column under reduced pressure. [Beilstein 16 IV 822.]

4-Chloroanisole(623-12-1)Related Product Information

• Artemether
• 1,2,4-Trichlorobenzene
• 1-Methoxy-2-propyl acetate
• Anisole
• Dimethyl ether
• Chlorphenamine maleate
• Dimefluthrin
• 4-Chlorostyrene
• 4'-CHLOROACETANILIDE
• 4-Methylsulfuryl chlorobenzene
• 4-Chlorobenzaldehyde
• 4-Chlorobenzamide
• 4-Methoxyphenol
• 4-Methylanisole
• p-Anisidine
• 4-Chlorobenzyl cyanide
• 4-Chlorobenzoic acid
• 2-Chloroanisole