3-Amino-2-pyridinecarboxylic acid Chemical Properties

Melting point:

218-220

Boiling point:

386.6±27.0 °C(Predicted)

Density 

1.417±0.06 g/cm3(Predicted)

RTECS 

US5175000

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

Soluble in acetone, ethanol and methanol.

pka

1.32±0.50(Predicted)

form 

Solid

color 

Yellow to pale brown

InChI

InChI=1S/C6H6N2O2/c7-4-2-1-3-8-5(4)6(9)10/h1-3H,7H2,(H,9,10)

InChIKey

BOOMHTFCWOJWFO-UHFFFAOYSA-N

SMILES

C1(C(O)=O)=NC=CC=C1N

CAS DataBase Reference

1462-86-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37-60

HazardClass 

IRRITANT

HS Code 

29333990

3-Amino-2-pyridinecarboxylic acid Usage And Synthesis

Chemical Properties

Green/Brown Crystals

Uses

Employed as an important intermediate for syntheses material and pharmaceutical.

Uses

3-Amino-2-pyridinecarboxylic acid is a useful synthetic intermediate.

Application

3-Aminopicolinic Acid is used in the preparation of piperidinyl-methyl-purinamines as NSD2 inhibitors and anti-cancer agents.

Synthesis

(2) Preparation of 3-aminopyridine-2-carboxylic acid: 3-nitropyridine-2-carboxylic acid (2.72 g, 16.2 mmol) and sodium bicarbonate (1.34 g, 16.2 mmol) were dissolved in distilled water (20 mL). The atmosphere in the system was replaced with nitrogen to exclude oxygen. After adding 10% palladium carbon catalyst (1.72 g), the atmosphere in the system was replaced with hydrogen and the reaction was stirred at room temperature for 50 hours. After completion of the reaction, the pH of the reaction solution was adjusted to weakly acidic by adding 1N aqueous hydrochloric acid. The solvent was removed by distillation under reduced pressure and a small amount of ethanol and ethyl acetate was added to the residue and the resulting precipitate was collected by filtration. The filtrate was concentrated to afford the target product 3-aminopyridine-2-carboxylic acid (1.50 g, 67% yield) as a light yellow solid.

References

[1] Patent: US2005/182045, 2005, A1. Location in patent: Page/Page column 74

3-Amino-2-pyridinecarboxylic acid(1462-86-8)Related Product Information

• ALTRENOGEST
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• Quinolinic acid
• Folic acid
• 3-Aminopyridine
• Chromium picolinate
• 2,5-PYRIDINEDICARBOXYLIC ACID
• 4-Dimethylaminopyridine
• 6-Aminocaproic acid
• Glycine
• 4-Aminobenzoic acid
• Methyl anthranilate
• Ethyl 2-(Chlorosulfonyl)acetate
• Tris(hydroxymethyl)aminomethane
• Citric acid
• Ascoric Acid
• Anthranilic acid