Propargyl-PEG5-tetra-Ac-beta-D-galactose CAS#: 1397682-61-9

Propargyl-PEG5-tetra-Ac-beta-D-galactose Basic information

Product Name:

Propargyl-PEG5-tetra-Ac-beta-D-galactose

Synonyms:

Propargyl-PEG5-tetra-Ac-beta-D-galactose
Propargyl-PEG4-tetra-Ac-beta-D-galactose
β-D-Galactopyranoside, 3,6,9,12-tetraoxapentadec-14-yn-1-yl, 2,3,4,6-tetraacetate
(2R,3R,4S,5S,6R)-2-((3,6,9,12-Tetraoxapentadec-14-yn-1-yl)oxy)-6-(acetoxymethyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

CAS:

1397682-61-9

MF:

C25H38O14

MW:

562.57

Mol File:

1397682-61-9.mol

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Propargyl-PEG5-tetra-Ac-beta-D-galactose Chemical Properties

Boiling point:: 583.7±50.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)

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Propargyl-PEG5-tetra-Ac-beta-D-galactose Usage And Synthesis

Description

Propargyl-PEG5-tetra-Ac-beta-D-galactose is a Click Chemistry-ready crosslinker containing a propargyl group and beta-D-galactose. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. D-galactose increases solubility in aqueous media and a the selectivity of the PEGlation reaction.

Uses

Propargyl-PEG4-tetra-Ac-beta-D-galactose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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