Propargyl-PEG4-S-PEG4-acid Chemical Properties

Boiling point:

591.5±50.0 °C(Predicted)

Density 

1.141±0.06 g/cm3(Predicted)

pka

4.28±0.10(Predicted)

Propargyl-PEG4-S-PEG4-acid Usage And Synthesis

Description

Propargyl-PEG4-S-PEG4-acid is a PEG linker containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Propargyl-PEG4-S-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-S-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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