ZK 756326
ZK 756326 Basic information
- Product Name:
- ZK 756326
- Synonyms:
-
- ZK 756326
- 2-(2-(4-(3-phenoxybenzyl)piperazin-1-yl)ethoxy)ethanoldihydrochloride
- 2-[2-[4-[(3-Phenoxyphenyl)methyl]piperazin-1-yl]-ethoxy]-ethanol
- ZK756326 2HCl
- 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanoldihydrochloride
- CS-2219
- 2-[2-[4-[(3-Phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol
- Ethanol, 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]-
- CAS:
- 874911-96-3
- MF:
- C21H28N2O3
- MW:
- 356.46
- Mol File:
- 874911-96-3.mol
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ZK 756326 Chemical Properties
- storage temp.
- Desiccate at RT
- form
- White solid.
- Water Solubility
- Soluble to 100 mM in water
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ZK 756326 Usage And Synthesis
Uses
2-?[2-?[4-?[(3-?Phenoxyphenyl)?methyl]?-?1-?piperazinyl]?ethoxy]?-ethanol is a nonpeptide CCR8 chemokine receptor agonist that inhibits the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 muM (1). It is a useful compound to investigate the physiological role of CCR8 in HIV infection.
Biological Activity
Selective, non-peptide CCR8 chemokine receptor agonist (IC 50 values are 1.8 and 2.6 μ M for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α 2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
ZK 756326Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Tongling HengYou Biotechnology Co., Ltd.
- Tel
- 021-50426030 13856289449
- 2630597085@qq.com