ZK 112993
ZK 112993 Basic information
- Product Name:
- ZK 112993
- Synonyms:
-
- ZK 112993
- 11β-(4-Acetylphenyl)-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
- CAS:
- 105114-63-4
- MF:
- C29H32O3
- MW:
- 428.56258
- Mol File:
- 105114-63-4.mol
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ZK 112993 Usage And Synthesis
Uses
ZK112993 is a potent progesterone receptor (PR) antagonist. ZK112993 significantly inhibits the growth of T61 human tumors in nude mice[1].
References
[1] C A Sartorius, et al. Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem. 1993 May 5;268(13):9262-6. PMID:8387487
[2] Claudia Lanari, et al.? Antiprogestins in breast cancer treatment: are we ready? Endocr Relat Cancer. 2012 May 3;19(3):R35-50. DOI:10.1530/ERC-11-0378