ZK-261991
ZK-261991 Basic information
- Product Name:
- ZK-261991
- Synonyms:
-
- ZK-261991
- ZK261991(ZK991)
- ZK 991
- ZK261991;ZK-261991;ZK 261991;ZK-991;ZK 991
- ZK-991
- Benzamide, 2-[[[2-[[(dimethylamino)carbonyl]amino]-4-pyridinyl]methyl]amino]-N-(2-methyl-2H-indazol-6-yl)-
- ZK 261991,ZK261991
- CAS:
- 886563-25-3
- MF:
- C24H25N7O2
- MW:
- 443.5
- Mol File:
- 886563-25-3.mol
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ZK-261991 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
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ZK-261991 Usage And Synthesis
Uses
ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2.
in vivo
ZK991 results in a significantly reduced recruitment of CD11b+ and LYVE-1+ cells into the murine cornea. ZK991 significantly improves the graft survival rate after corneal transplantation[1].
IC 50
VEGFR2: 5 nM (IC50)
References
[1] Deniz Hos, et al. Inflammatory Corneal (Lymph)angiogenesis Is Blocked by VEGFR-Tyrosine Kinase Inhibitor ZK 261991, Resulting in Improved Graft Survival after Corneal Transplantation. Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1836-184
ZK-261991Supplier
MedChemexpress LLC
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- 021-58955995
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SPIRO PHARMA
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- eric_feng1954@126.com
Shenzhen Regent Biochemical Technology Co., Ltd.
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TargetMol Chemicals Inc.
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