ZK824859
ZK824859 Basic information
- Product Name:
- ZK824859
- Synonyms:
-
- CS-2839
- ZK824859
- ZK824859;ZK-824859;ZK 824859;2254001-81-3
- ZK824190
- Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, (2R)-
- Inhibitor,Serine endopeptidases,protease,multiple sclerosis,plasminogen,Urokinase,Plasminogen activator inhibitor-1,Serine,Serine proteases,Ser/Thr Protease,ZK-824190,uPA,Threonine proteases,ZK824190,inhibit,ZK 824190,PAI-1
- (R)-2-((6-((3'-(aminomethyl)-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid
- ZK824190, 10 mM in DMSO
- CAS:
- 2254001-81-3
- MF:
- C22H20F2N2O4
- MW:
- 414.4
- Mol File:
- 2254001-81-3.mol
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ZK824859 Chemical Properties
- solubility
- DMSO: Soluble
Methanol: Soluble
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ZK824859 Usage And Synthesis
Uses
ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].
in vivo
ZK824190 (2?mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h)[1].
| Animal Model: | Rats with experimental autoimmune encephalomyelitis (EAE) model[1] |
| Dosage: | 2?mg/kg (Pharmacokinetic Analysis) |
| Administration: | PO |
| Result: | Oral availability F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL; T1/2=2.8 h. |
References
[1] Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. DOI:10.1016/j.bmcl.2018.09.001
ZK824859Supplier
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com
Shanghai Chaolan Chemical Technology Center
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- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com