ZK164015 Chemical Properties

Boiling point:

712.4±55.0 °C(Predicted)

Density 

1.13±0.1 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

Soluble to 25 mM in ethanol and to 100 mM in DMSO

form 

Powder

pka

10.17±0.15(Predicted)

ZK164015 Usage And Synthesis

Uses

ZK 164015 is a potent ER silent antagonist.

Definition

ChEBI: 2-(4-hydroxyphenyl)-3-methyl-1-(10-pentylsulfonyldecyl)-5-indolol is a phenylindole.

Biological Activity

Potent estrogen receptor silent antagonist. Inhibits 17b-estradiol stimulation of luciferase activity (IC 50 = 0.025 mM) and potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC 50 ~ 1 nM).

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