ZK-90055 (hydrochloride)
ZK-90055 (hydrochloride) Basic information
- Product Name:
- ZK-90055 (hydrochloride)
- Synonyms:
-
- ZK-90055 (hydrochloride)
- ZK 90055 hydrochloride,ZK90055 hydrochloride
- CAS:
- 84638-81-3
- MF:
- C16H23ClN2O4
- MW:
- 342.82
- Mol File:
- 84638-81-3.mol
ZK-90055 (hydrochloride) Chemical Properties
- Melting point:
- 187-190 °C (decomp)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
ZK-90055 (hydrochloride) Usage And Synthesis
Uses
ZK-90055 hydrochloride is a β2 adrenergic receptor agonist.
in vivo
Contrasting a pro-drug, a soft-drug is active per se when given locally but is rapidly inactivated when it reaches the general circulation. Thus, a long duration of action at a minimum of systemic side effects may be achieved after inhalation of a h2-agonist designed in this way. One such example is ZK-90055, an indol derivative with a hydrolysable ester bond on the ring system. The development of ZK-90055 is stopped before clinical trials are commenced[2].
References
[1] Waldeck B, et al. beta-Adrenoceptor agonists after terbutaline. Pharmacol Toxicol. 1995;77 Suppl 3:25-9. DOI:10.1111/j.1600-0773.1995.tb01937.x
[2] Waldeck B, et al. Beta-adrenoceptor agonists and asthma--100 years of development. Eur J Pharmacol. 2002 Jun 7;445(1-2):1-12. DOI:10.1016/s0014-2999(02)01728-4
ZK-90055 (hydrochloride)Supplier
- Tel
- 021-58955995
- sales@medchemexpress.cn
- Tel
- 021-52996696，15000506266 15000506266
- Tel
- 15911056312
- liming@bio-fount.com
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Tel
- info@bocsci.com