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Yangambin

Basic information Safety Supplier Related

Yangambin Basic information

Product Name:
Yangambin
Synonyms:
  • Lrioresinol B dimethyl ether
  • (1S,3aR,4S,6aR)-Tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan
  • (+)-Yangabin
  • C10894
  • YANGAMBIN
  • (+)-O,O-Dimethyl lirioresinol B
  • (1S)-1β,4β-Bis(3,4,5-trimethoxyphenyl)-3aβ,4,6,6aβ-tetrahydro-1H,3H-furo[3,4-c]furan
  • (1β,5β)-2β,6β-Bis(3,4,5-trimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane
CAS:
13060-14-5
MF:
C24H30O8
MW:
446.49
Mol File:
13060-14-5.mol
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Yangambin Chemical Properties

Melting point:
105-106 °C
Boiling point:
556.1±50.0 °C(Predicted)
Density 
1.183±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
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Yangambin Usage And Synthesis

Uses

Yangambin is one of the active ingredients of Radix Stellerae Chamaejasmes, which is bitter in nature and taste, and is highly toxic. It has the effects of severe diarrhea, prevent decay, and swelling. It is clinically used for erysipelas, mammary carbuncle, swollen mumps (mumps), yellow water sores, and acne.

Definition

ChEBI: Yangambin is a lignan.

Biological Activity

Yangambin is a furofuran lignan that has been isolated from plants such as the Annonaceae family, including: R. pickeli, R. exalbida and R. mucosa and Magnolia biondii. Yangambin is a selective PAF receptor antagonist that inhibits Ca2+ influx by modulating Ca2+ channels, resulting in a decrease in [Ca2+] in vascular smooth muscle cells and subsequent peripheral vasodilation. Yangambin exhibits anti-allergic activity against β-hexosaminidase with IC50 of 33.8 μM and anti-inflammatory activity with IC50 of 37.4 μM.

YangambinSupplier

Chengdu Caoyuankang Biological Technology Co., Ltd. Gold
Tel
134-38890071 13438890071
Email
3003796344@qq.com
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Email
y.liu@mail.biobiopha.com
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Email
cwb1@biopurify.cn
Shanghai Winherb Medical Technology Co., Ltd.
Tel
400-400-186-5138 13341702378
Email
winherb@126.com
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Email
aileen@chemfaces.com