3-(Trifluoromethoxy)iodobenzene Chemical Properties

Boiling point:

185-186 °C (lit.)

Density 

1.863 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.5200(lit.)

Flash point:

135 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light red to Green

Sensitive 

Light Sensitive

CAS DataBase Reference

198206-33-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29093090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-(Trifluoromethoxy)iodobenzene Usage And Synthesis

Synthesis

1. 3-Trifluoromethoxyaniline (17.7 g, 100.00 mmol) was dissolved in H2O (80 ml) at -5 °C and an aqueous solution of NaNO2 (7.4 g, 115.62 mmol) was added. 2. H2SO4 (25 g, 250.00 mmol) was added slowly and dropwise with stirring, keeping the reaction temperature at -5 °C. 3. The reaction mixture was maintained at -5 °C for 15 min. 4. H2O (60 ml) solution of KI (20 g, 120.48 mmol) was added dropwise. 5. The reaction solution was brought to room temperature and stirred overnight. 6. The reaction mixture was extracted with EtOAc (2 x 100 mL). 7. The organic layers were combined, washed with Na2SO3/H2O (2 x 50 mL), dried over Na2SO4 and concentrated in vacuum. 8. The residue was purified by silica gel column chromatography to afford 1-iodo-3-(trifluoromethoxy)benzene (4.0 g, 14% yield).

References

[1] Patent: WO2006/55187, 2006, A1. Location in patent: Page/Page column 99-100

3-(Trifluoromethoxy)iodobenzene(198206-33-6)Related Product Information

• (Diacetoxyiodo)benzene
• p-Trifluoromethoxy phenol
• 1,4-Diiodobenzene
• 4-Iodoanisole
• 4-Methoxybenzyl alcohol
• 4-(Trifluoromethoxy)benzaldehyde
• 2-(Trifluoromethoxy)aniline
• 3-(Trifluoromethoxy)aniline
• Iodobenzene
• 1,2-Diiodobenzene
• Xylene
• 3-(METHOXYMETHOXY)BENZALDEHYDE
• p-Anisaldehyde
• 4-Methoxyphenylacetic acid
• 4-(Trifluoromethoxy)aniline
• Trimethyl phosphite
• Benzene
• 4-(Trifluoromethoxy)chlorobenzene