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SHIONONE

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SHIONONE Basic information

Product Name:
SHIONONE
Synonyms:
  • SHIONONE
  • 2(1H)-Chrysenone,hexadecahydro-1,4b,6a,8,10a,12a-
  • hexamethyl-8-(4-methyl-3-pentenyl)-,(1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-
  • 18,19-Seco-D:A-friedolup-19-en-3-one
  • 3β,5,8,17aβ-Tetramethyl-3-(4-methyl-3-pentenyl)-D-homo-5α-androstan-17-one
  • Shionone ,98%
  • 21-Shionen-3-one
  • Shionone, 98%, from Aster tataricus L. f.
CAS:
10376-48-4
MF:
C30H50O
MW:
426.72
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
10376-48-4.mol
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SHIONONE Chemical Properties

Melting point:
161-162°
alpha 
D26.5 -56.1° (c = 1.07 in chloroform)
Boiling point:
485.6±14.0 °C(Predicted)
Density 
0.941±0.06 g/cm3(Predicted)
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
color 
White to off-white
optical activity
-56.126.5 (c 1.07, CHCl3)
LogP
10.401 (est)
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Safety Information

Safety Statements 
24/25
HS Code 
29143990
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SHIONONE Usage And Synthesis

Uses

Shionone is an effective inhibitor of human neutrophil elastase which may be used as a treatment for inflammatory lung diseases including H1N1 and SARS virus infections.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Aster tataricus.

Uses

Shionone is an effective inhibitor of human neutrophil elastase which may be used as a treatment for inflammatory lung diseases including H1N1 and SARS virus infections.

Definition

ChEBI: A tetracyclic triterpenoid that is perhydrochrysene which is substituted by methyl groups at positions 1, 4bbeta, 6aalpha, 8beta, 10abeta and 12a positions, by a 4-methylpent-3-enyl group t the 8alpha position, and with an oxo group at position 2.

in vivo

Shionone (orally administration; 80 mg/kg; 3 days; once daily) shows the trend of enhancing sputum secreting, but has no effect on ammonia-induced cough and reduces xylene-induced ear edema[1].

Animal Model:ICR male mice[1]
Dosage:80 mg/kg
Administration:Orally administration; 3 days; once daily
Result:Reduced the ear edema for 11.3% by use shionone.

target

ERK | IkB | NOS | IKK

SHIONONESupplier

Chembest Research Laboratories Limited
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BeiJing Hwrk Chemicals Limted
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0757-86329057 18934348241
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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BioBioPha Co., Ltd.
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0871-65217109 13211707573;
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y.liu@mail.biobiopha.com
Chengdu Ai Keda Chemical Technology Co., Ltd.
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4008-755-333 18080918076
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800078821@qq.com
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