licarin B
licarin B Basic information
- Product Name:
- licarin B
- Synonyms:
-
- 1,3-Benzodioxole,5-[(2R,3R)-2,3-dihydro-7-Methoxy-3-Methyl-5-(1E)-1-propenyl-2-benzofuranyl]-(9CI)
- licarin B
- 5-[(2S)-2,3-Dihydro-7-methoxy-3β-methyl-5-[(E)-1-propenyl]benzofuran-2-yl]-1,3-benzodioxole
- 5-((2R,3R)-2,3-Dihydro-7-methoxy-3-methyl-5-(1E)-1-propenyl-2-benzofuranyl)-1,3-benzodioxole
- 5-[(3S)-7-methoxy-3-methyl-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran-2-yl]-1,3-benzodioxole
- Licarine B
- 1,3-Benzodioxole, 5-[(2R,3R)-2,3-dihydro-7-methoxy-3-methyl-5-(1E)-1-propen-1-yl-2-benzofuranyl]-
- (-)-Licarin B
- CAS:
- 51020-87-2
- MF:
- C20H20O4
- MW:
- 324.37
- EINECS:
- 2017-001-1
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- reagent
- standard substance
- Mol File:
- 51020-87-2.mol
licarin B Chemical Properties
- Boiling point:
- 428.5±45.0 °C(Predicted)
- Density
- 1.201±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- powder
- color
- White
licarin B Usage And Synthesis
Chemical Properties
White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from nutmeg, Lauraceae (Lauraceae) Licarin aritu Ducke trunk (yield: 0.35%) Machilus japonica Sieb.et Zucc. Ye Hongnan Machilus thunbergii Sieb.et Zucc. Bark, wood, leaves.
Uses
Licarin B has antibacterial, anti-inflammatory, sedative and anti-tumor effects.
Biological Activity
Licarin B, derived from the seeds of Myristica fragrans, is an inhibitor of NO production and improves insulin sensitivity by activating PPARγ and GLUT4 in the IRS-1/PI3K/AKT pathway.
in vitro
Licarin B (5 μM, 10 μM, 15 μM. 8 days) moderately increases TG accumulation during adipogenic differentiation and showed partial PPARg agonist activity in 3T3-L1 preadipocytes.
Cell Viability Assay < /p>
| Cell Line: | 3T3-L1 cell. |
| Concentration: | 1-500 μM. |
| Incubation Time: | 48 h. |
| Result: | Did not cause significant cell death up to 500 μM concentration. |
Cell Viability Assay
| Cell Line: | 3T3-L1 cell. | |
| Concentration: | 5 μM, 10 μM, 15 μM. | |
| Incubation Time: | 8 days (replaced every 2 days). | 8 days (replaced every 2 days). | td>
| Result: | LB at 15 μM concentration significantly promoted adipocyte differentiation and caused intracellular TG accumulation. |
target
PPAR | GLUT | PI3K | Akt | IRS-1
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licarin B(51020-87-2)Related Product Information
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- Artemether
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- TRIMYRISTIN