GANGLIOSIDE GM2 SODIUM SALT Chemical Properties

storage temp. 

-20°C

solubility 

chloroform/methanol (9:1): 10 mg/mL, clear, slightly yellow

form 

A solid

Safety Information

WGK Germany 

3

F 

10-21

HS Code 

29389090

MSDS

• Language:English Provider:SigmaAldrich

GANGLIOSIDE GM2 SODIUM SALT Usage And Synthesis

Uses

Monosialoganglioside GM2 from bovine brain has been used:

• to study the effects of GM2 supplementation and depletion of all cellular ganglioside subspecies on neurite outgrowth and neuronal survival using canine dorsal root ganglia (DRG) neurons
• as a reference standard for high-performance thin-layer chromatography (HPTLC) and as antigens for enzyme-linked immunosorbent assay (ELISA) to analyze the ganglioside signatures of human prostate cancer (CaP) cells
• as a component of the reaction buffer to perform in vitro activity assay of GM1 synthase

General Description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage. For classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Biochem/physiol Actions

Minor component of cell membranes that has been shown to accumulate in Tay-Sachs disease.

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