ELASTIN Chemical Properties

storage temp. 

2-8°C

solubility 

H₂O: soluble

form 

powder

InChIKey

DPUYCSDGMSDKKV-XPEWSIIXNA-N

SMILES

N1(C(=O)[C@@H](NC(CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)[C@@H](C)CC)=O)C(C)C)CCC[C@H]1C(NC)=O |&1:3,10,14,23,34,r|

LogP

0.693 (est)

Safety Information

Hazard Codes 

B

Safety Statements 

22-24/25

WGK Germany 

3

F 

10-21

MSDS

• Language:English Provider:SigmaAldrich

ELASTIN Usage And Synthesis

Uses

elastin (hydrolyzed) is a modified form of elastin that has better solubility, and thus is more convenient for use in cosmetic formulations than regular elastin.

Uses

elastin is a surface protective agent used in cosmetics to alleviate the effects of dry skin, enhance skin flexibility, improve skin feel, increase and improve the tension of the skin, and influence the formation of tropocollagen fibers when used in combination with soluble collagen. Preparations containing elastin and peptides derived from it are reported to promote wound healing. Reportedly, in such systems, elastin can absorb lipids from the skin, and when applied to scars, increase the structural glycoproteins and elastin available in the scar tissue. elastin is an elastic structural protein found in the dermis together with collagen, and is difficult to obtain in pure form. Collagen and elastin are similar, although elastin has a different amino acid composition and is found in lower concentrations. Its molecular size is also much smaller than collagen’s, and as a result, there is a tendency to believe that it penetrates the surface epidermal layers, thereby improving overall skin appearance, softness, and suppleness. elastin is often used in moisturizing products and those products for aging or mature skin.

Uses

Elastin mouse lung has been used as an extracellular matrix (ECM) protein for coating of plates.

Definition

A fibrous protein that is themajor constituent of the yellow elasticfibres of connective tissue. It isrich in glycine, alanine, proline, andother nonpolar amino acids that arecross-linked, making the protein relativelyinsoluble. Elastic fibres canstretch to several times their lengthand then return to their original size.Elastin is particularly abundant inelastic cartilage, blood-vessel walls,ligaments, and the heart.

General Description

Elastin is an extracellular matrix protein encoded by the gene ELN, which is mapped to human chromosome 7q11.23. Elastin is a major protein component of elastic fibres and is synthesized from the precursor protein called tropoelastin. Elastin is present in all the vertebrates except for the primitive fish. Elastin is majorly composed of glycine, proline and other hydrophobic residues.

General Description

Elastin is an insoluble extracellular matrix protein and the core protein of elastic fibers that impart elasticity to skin. Histologically, an accumulation of disintegrated amorphous elastic fibers is observed in the solar elastosis region. Elastin is secreted as tropoelastin in the extracellular matrix. The biologic process of elastic fibers is complicated. It has multiple components and is assembled via several steps and stringently regulated developmental processes.

Biochem/physiol Actions

Protein responsible for the elasticity of many tissues. It is especially important in blood vessels, where it comprises about 50% of the dry tissue weight.

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