DISIALOGANGLIOSIDE GD1B 2NA Chemical Properties

storage temp. 

−20°C

solubility 

Chloroform:Methanol:DI Water (2:1:0.1): soluble

form 

lyophilized powder

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

10-21

HS Code 

29400090

MSDS

• Language:English Provider:SigmaAldrich

DISIALOGANGLIOSIDE GD1B 2NA Usage And Synthesis

Description

Ganglioside G_D1b is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events. The concentration of ganglioside G_D1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects. Ganglioside G_D1b levels are positively correlated with pilocytic astrocytoma tumor grade, and G_D1b has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas. Ganglioside G_D1b mixture contains ganglioside G_D1b molecular species with C18:1 and C20:1 fatty acyl chains.

Uses

Ganglioside GD1b Disodium Salt (Bovine Brain) is a ganglioside, major constituents of neuronal cell membranes and endoplasmic reticulum that have been shown to modulate cell signal transduction.

General Description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Biochem/physiol Actions

May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.

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